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Invitrogen
SERPINB3/SERPINB4 Polyclonal Antibody
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SERPINB3/SERPINB4 Antibody (PA5-145441) in IHC (P)
Immunohistochemistry (Paraffin) analysis of SERPINB3/SERPINB4 in Human Prostate cancer Tissue. Samples were incubated in SERPINB3/SERPINB4 polyclonal antibody (Product # PA5-145441) using a dilution of 20 µg/mL followed by HRP-Linked Caprine Anti-Rabbit IgG at a dilution of 2 µg/mL and DAB staining.
Product Details
PA5-145441
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human SCCA1/SCCA2 protein, Leu38-Gln215 (Accession #Q5K684)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography, Protein A
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% Proclin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Metastasis of a primary tumor to a distant site is determined through signaling cascades that break down interactions between the cell and extracellular matrix proteins. Among the proteins mediating metastasis are serine prote-ases, such as neutrophil elastase. In 1985, Dr. Jim Travis and Dr. R.W. Carrell designated an emerging family of serine protease inhibitors as the serpin fam-ily, which share homology in both primary amino acid sequence and tertiary structure. Serpins contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. Serine proteases bind to this substrate mimic in a 1:1 stoichiometric fashion and become catalytically inactive. Aberrant ex-pression of serpin family members can contribute to a number of conditions, including emphysema (a-1 antitrypsin deficiency), fatal bleeding (elastase to thrombin specificity) and thrombosis (antithrombin deficiency), and are indicators of cancer stage phenotypes (circulating levels of squamous cell carcinoma antigen, known as SCCA1, increase in advancing stages of some cervical, lung, esophageal and head and neck cancers). Human chromosome position 18q21.3 contains a cluster of serpins, including a tandem duplication of the SCCA gene, plasminogen activator inhibitor type 2, and maspin. SCCA is transcribed by two nearly identical genes (SCCA1 and SCCA2), and is mainly produced as SCCA1. The human SCCA1 gene encodes a 390 amino acid protein that was originally isolated from a metastatic cervical squamous cell carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Leupin; Peptidase inhibitor 11; PI-11; protease inhibitor (leucine-serpin); Protein T4-A; SCCA-1; SCCA-2; SCCA2/SCCA1 fusion protein; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 4; Serpin B3; Serpin B4; serpin peptidase inhibitor, clade B (ovalbumin), member 3; serpin peptidase inhibitor, clade B (ovalbumin), member 4; spb3; Squamous cell carcinoma antigen 1; Squamous cell carcinoma antigen 2
Gene Aliases: HsT1196; LEUPIN; PI11; SCC; SCCA; SCCA-1; SCCA-2; SCCA-PD; SCCA1; SCCA2; SERPINB3; SERPINB4; SSCA1; T4-A
UniProt ID: (Human) P29508, (Human) P48594
Entrez Gene ID: (Human) 6317, (Human) 6318
positive regulation of cell proliferation
negative regulation of peptidase activity
positive regulation of epithelial to mesenchymal transition
positive regulation of endopeptidase activity
negative regulation of endopeptidase activity
positive regulation of cell migration
autocrine signaling
paracrine signaling
negative regulation of catalytic activity
negative regulation of JUN kinase activity
negative regulation of proteolysis
viral entry into host cell
regulation of proteolysis
protection from natural killer cell mediated cytotoxicity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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