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Invitrogen
SERPINB3/SERPINB4 Polyclonal Antibody
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FIGURE: 1 / 1
SERPINB3/SERPINB4 Antibody (PA5-75841) in WB
Western blot analysis of SERPINB3/SERPINB4 in Line 1: THP-1 whole cell lysate, Line 2: PC12 whole cell lysate, Line 3: sp20 whole cell lysate. Samples were incubated with SERPINB3/SERPINB4 polyclonal antibody (Product # PA5-75841) at a dilution of 1:500.
Product Details
PA5-75841
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues in Human SERPINB3/SERPINB4.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
Metastasis of a primary tumor to a distant site is determined through signaling cascades that break down interactions between the cell and extracellular matrix proteins. Among the proteins mediating metastasis are serine prote-ases, such as neutrophil elastase. In 1985, Dr. Jim Travis and Dr. R.W. Carrell designated an emerging family of serine protease inhibitors as the serpin fam-ily, which share homology in both primary amino acid sequence and tertiary structure. Serpins contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. Serine proteases bind to this substrate mimic in a 1:1 stoichiometric fashion and become catalytically inactive. Aberrant ex-pression of serpin family members can contribute to a number of conditions, including emphysema (a-1 antitrypsin deficiency), fatal bleeding (elastase to thrombin specificity) and thrombosis (antithrombin deficiency), and are indicators of cancer stage phenotypes (circulating levels of squamous cell carcinoma antigen, known as SCCA1, increase in advancing stages of some cervical, lung, esophageal and head and neck cancers). Human chromosome position 18q21.3 contains a cluster of serpins, including a tandem duplication of the SCCA gene, plasminogen activator inhibitor type 2, and maspin. SCCA is transcribed by two nearly identical genes (SCCA1 and SCCA2), and is mainly produced as SCCA1. The human SCCA1 gene encodes a 390 amino acid protein that was originally isolated from a metastatic cervical squamous cell carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Leupin; Peptidase inhibitor 11; PI-11; protease inhibitor (leucine-serpin); Protein T4-A; SCCA-1; SCCA-2; SCCA2/SCCA1 fusion protein; serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3A; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 4; serine peptidase inhibitor, clade B, member 3A; serine protease inhibitor; serine protease inhibitor B3; serpin; Serpin B3; Serpin B4; serpin peptidase inhibitor, clade B (ovalbumin), member 3; serpin peptidase inhibitor, clade B (ovalbumin), member 4; spb3; Squamous cell carcinoma antigen 1; Squamous cell carcinoma antigen 2; unnamed protein product
Gene Aliases: 1110001H02Rik; 1110013A16Rik; HsT1196; LEUPIN; PI11; RGD1562868; SCC; SCCA; SCCA-1; SCCA-2; SCCA-PD; SCCA1; SCCA2; SERPINB3; SERPINB4; Sqn5; SSCA1; T4-A
UniProt ID: (Human) P29508, (Human) P48594
Entrez Gene ID: (Human) 6317, (Human) 6318, (Rat) 304688, (Mouse) 20248, (Rat) 498209
positive regulation of cell proliferation
negative regulation of peptidase activity
positive regulation of epithelial to mesenchymal transition
positive regulation of endopeptidase activity
negative regulation of endopeptidase activity
positive regulation of cell migration
autocrine signaling
paracrine signaling
negative regulation of catalytic activity
negative regulation of JUN kinase activity
negative regulation of proteolysis
viral entry into host cell
regulation of proteolysis
protection from natural killer cell mediated cytotoxicity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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