Immunogen sequence: MSAPAAKVSK KELNSNHDGA DETSEKEQQE AIEHIDEVQN EIDRLNEQAS EEILKVEQKY NKLRQPFFQK RSELIAKIPN FWVTTFVNHP QVSALLGEED EEALHYLTRV EVTEFEDIKS GYRIDFYFDE NPYFENKVLS KEFHLNESGD PSSKSTEIKW KSGKDLTKRS SQTQNKASRK RQHEEPESFF TWFTDHSDAG ADELGEVIKD DIWPNPLQYY LVPDMDDEEG EGEEDDDDDE EEEGLEDIDE EGDEDEGEED EDDDEGEEGE EDEGEDD; Positive Samples: 293T, MCF7, HeLa; Cellular Location: Cytoplasm, Endoplasmic reticulum, Nucleus, cytosol, nucleoplasm
SET is a multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone binding. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HLA-DR-associated protein II; I IGAAD; I-2PP2A; IGAAD; Inhibitor of granzyme A-activated DNase; inhibitor-2 of protein phosphatase-2A; Liver regeneration-related protein LRRGR00002; OTTHUMP00000022286; PHAPII; Phosphatase 2A inhibitor I2PP2A; protein phosphatase type 2A inhibitor; Protein SET; RP11-216B9.3; SET nuclear oncogene; SET translocation; SET translocation (myeloid leukemia-associated); TAF-1a; TAF-1b; TAF-I; Template-activating factor I; Template-Activating Factor-I, chromatin remodelling factor
Gene Aliases: 2610030F17Rik; 2PP2A; 5730420M11Rik; AA407739; Ab1-115; I-2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII; SET; StF-IT-1; TAF-I; TAF-IBETA