Immunogen sequence: LLQGTGVPEA VEKDLANIRS EYQSIVLPFM EAHPDLFSLR VRSLELYHQL VALVMAYSFQ EPLEEEEDEK EPN
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 90%.
SETD6 (SET domain-containing protein 6) is a 473 amino acid protein that belongs to the SETD6 family. Containing one SET domain, SETD6 is structurally similar to the Rubisco large subunit methyltransferase. SETD6 is a proteinlysine N-methyltransferase that specifically monomethylates "Lys-310" of the NFκB p65 subunit of NFκB complex, leading to down-regulate NFκB transcription factor activity. SETD6-mediated methylation renders NFκB p65 inert and attenuates NFκB p65-driven transcriptional programs, including inflammatory responses in primary immune cells. The SETD6-initiated lysine-methylation signaling cascade acts to restrain activation of NFκB-mediated inflammatory responses in diverse cell types.
Protein Aliases: N-lysine methyltransferase SETD6; SET domain-containing protein 6
Gene Aliases: SETD6
UniProt ID: (Human) Q8TBK2
Entrez Gene ID: (Human) 79918
Molecular Function: methyltransferase