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Invitrogen
SETMAR Polyclonal Antibody
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FIGURE: 1 / 1
SETMAR Antibody (720343) in WB
Western blot analysis was performed on Nuclear extracts (30 µg lysate) of SH-SY5Y (Lane 1), HEL 92.1.7 (Lane 2), NTERA-2 (Lane 3) and U-2 OS (Lane 4). The blots were probed with Anti-SETMAR Rabbit Polyclonal Antibody (Product # 720343, 1-2 µg/mL) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal Secondary Antibody, HRP conjugate (Product # A27036, 0.4 µg/mL, 1:2500 dilution). Two isoforms of 78 kDa, 41 kDa (cell lines) and 62 kDa (mouse muscle) corresponding to SETMAR was observed. Known quantity of pro... View More
Product Details
720343
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Protein corresponding to human SETMAR [aa15-aa303]
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 30% glycerol, 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with Monkey, Bovine, Sheep
Target Information
SETMAR (SET domain and mariner transposase fusion gene) is a histone methyltransferase that methylates Lys-4 and Lys-36 of histone H3, creating specific tags for epigenetic transcriptional activation. It specifically mediates dimethylation of H3 Lys-36. SETMAR has sequence-specific DNA-binding activity, and recognizes the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 transposable element. SETMAT has DNA nicking activity, and in vivo end-joining activity, and may mediate genomic integration of foreign DNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epidermal tumor expressed transcript 2; Histone-lysine N-methyltransferase SETMAR; Metnase; SET domain and mariner transposase fusion gene-containing protein; SET domain and mariner transposase fusion gene-containing protein homolog; SET domain and mariner transposase fusion protein; SET domain without mariner transposase fusion protein
Gene Aliases: 5830404F24Rik; Etet2; Mar1; METNASE; SETMAR
UniProt ID: (Human) Q53H47, (Mouse) Q80UJ9
Entrez Gene ID: (Human) 6419, (Mouse) 74729
single-stranded DNA endodeoxyribonuclease activity
double-stranded DNA binding
single-stranded DNA binding
endonuclease activity
protein binding
zinc ion binding
histone methyltransferase activity (H3-K4 specific)
protein homodimerization activity
structure-specific DNA binding
DNA topoisomerase binding
histone methyltransferase activity (H3-K36 specific)
methyltransferase activity
transferase activity
histone-lysine N-methyltransferase activity
metal ion binding
histone modifying enzyme
viral or transposable element protein
DNA double-strand break processing
DNA catabolic process, endonucleolytic
double-strand break repair via nonhomologous end joining
cell proliferation
histone H3-K36 methylation
DNA integration
replication fork processing
mitotic DNA integrity checkpoint
histone H3-K4 methylation
negative regulation of cell cycle arrest
nucleic acid phosphodiester bond hydrolysis
histone H3-K36 dimethylation
positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
positive regulation of double-strand break repair via nonhomologous end joining
negative regulation of chromosome organization
chromatin modification
methylation
histone lysine methylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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