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Invitrogen
SFRP2 (soluble) Polyclonal Antibody
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Product Details
PA5-148479
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse sFRP-2 (R&D Systems, Catalog # 1169-FR), Leu25-Cys295
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FRP 2; MGC128911; MGC153618; MGC53344; Protein SDF5; SARP 1; SARP-1; SDF 5; Secreted apoptosis-related protein 1; Secreted frizzled-related protein 2; secreted frizzled-related sequence protein 2; secreted frizzled-related sequence protein 5; sFRP 2; sFRP-2; Sfrp2 protein; stromal cell derived factor 5
Gene Aliases: AI851596; Sarp1; Sdf5; Sfrp2
UniProt ID: (Mouse) P97299
Entrez Gene ID: (Mouse) 20319
patterning of blood vessels
somitogenesis
neural tube closure
chondrocyte development
outflow tract morphogenesis
cardiac left ventricle morphogenesis
apoptotic process
signal transduction
multicellular organism development
positive regulation of cell proliferation
negative regulation of cell proliferation
male gonad development
anterior/posterior pattern specification
negative regulation of gene expression
negative regulation of cardiac muscle cell apoptotic process
negative regulation of epithelial to mesenchymal transition
positive regulation of endopeptidase activity
Wnt signaling pathway
neural tube development
regulation of Wnt signaling pathway
cell differentiation
negative regulation of Wnt signaling pathway
collagen fibril organization
positive regulation of cell growth
negative regulation of cell growth
negative regulation of cell migration
negative regulation of BMP signaling pathway
cellular response to extracellular stimulus
positive regulation of peptidyl-serine phosphorylation
positive regulation of catenin import into nucleus
post-anal tail morphogenesis
regulation of cell proliferation
response to drug
negative regulation of mesodermal cell fate specification
embryonic digit morphogenesis
regulation of apoptotic process
positive regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of JUN kinase activity
positive regulation of fat cell differentiation
positive regulation of osteoblast differentiation
positive regulation of angiogenesis
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
development of primary male sexual characteristics
digestive tract morphogenesis
negative regulation of epithelial cell proliferation
negative regulation of peptidyl-tyrosine phosphorylation
cartilage development
convergent extension involved in axis elongation
canonical Wnt signaling pathway
bone morphogenesis
negative regulation of dermatome development
hematopoietic stem cell proliferation
cellular response to X-ray
negative regulation of canonical Wnt signaling pathway
regulation of establishment of planar polarity
planar cell polarity pathway involved in neural tube closure
Wnt signaling pathway involved in somitogenesis
positive regulation of canonical Wnt signaling pathway
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
regulation of stem cell division
negative regulation of planar cell polarity pathway involved in axis elongation
positive regulation of receptor activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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