Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Frizzled-related protein 1b; FRP-1b; SARP-3; secreted apoptosis related protein 3; Secreted apoptosis-related protein 3; Secreted frizzled-related protein 5; secreted frizzled-related sequence protein 5; sFRP-5
Gene Aliases: AI605071; FRP1B; SARP3; SFRP5
Molecular Function: transmembrane signal receptor