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Invitrogen
TRA2B Polyclonal Antibody
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FIGURE: 1 / 7
TRA2B Antibody (PA5-30170) in IHC (P)
SFRS10 Polyclonal Antibody detects TRA2B protein at nucleus on rat fore brain by immunohistochemical analysis. Sample: Paraffin-embedded rat fore brain. SFRS10 Polyclonal Antibody (Product # PA5-30170) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
Product Details
PA5-30170
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human TRA2B. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.41 mg/mL
Amount
41 µg
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: JurKat.
Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (84%), Xenopus laevis (95%), Pig (100%), Chicken (99%), Sheep (99%), Rhesus Monkey (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
TRA2B (Transformer 2 Beta Homolog) is a serine/arginine-rich (SR-like) RNA-binding protein that functions as an important regulator of alternative pre-mRNA splicing. It binds to specific exonic splicing enhancer (ESE) sequences and promotes exon inclusion in a variety of target transcripts, thereby contributing to transcript diversity and post-transcriptional gene regulation. TRA2B plays roles in development, cell cycle regulation, and tissue-specific gene expression, and its dysregulation has been implicated in cancer and other diseases through altered splicing patterns. As part of the broader SR protein and splicing factor network, TRA2B interacts with additional components of the spliceosome to coordinate precise and context-dependent mRNA processing.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alternative splice variant of human splicing factor htra2-beta-1; protein phosphatase 1, regulatory subunit 156; RA301; serine/arginine-rich splicing factor 10; SIG-41; Silica-induced gene 41 protein; Splicing factor, arginine/serine-rich 10; splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila); TRA-2 beta; TRA2-beta; Transformer-2 protein homolog B; Transformer-2 protein homolog beta; unnamed protein product
Gene Aliases: 5730405G21Rik; D16Ertd266e; Htra2-beta; PPP1R156; SFRS10; SIG-41; Silg41; SRFS10; Srsf10; TRA2-BETA; TRA2B; TRA2beta; TRAN2B
UniProt ID: (Human) P62995, (Mouse) P62996, (Rat) P62997
Entrez Gene ID: (Human) 6434, (Mouse) 20462, (Rat) 117259
regulation of alternative mRNA splicing, via spliceosome
mRNA splicing, via spliceosome
mRNA processing
RNA splicing
cerebral cortex regionalization
positive regulation of mRNA splicing, via spliceosome
response to reactive oxygen species
RNA splicing, via transesterification reactions
regulation of RNA splicing
cellular response to glucose stimulus
embryonic brain development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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