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Invitrogen
SH3GL2 Polyclonal Antibody
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FIGURE: 1 / 2
SH3GL2 Antibody (PA5-101888) in ICC/IF
Immunocytochemistry analysis of SH3GL2 in Hela cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with SH3GL2 polyclonal antibody (Product # PA5-101888) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
Product Details
PA5-101888
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SH3GL2(Accession Q99962), corresponding to amino acid residues M51-G101.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total SH3GL2.
Target Information
Enables identical protein binding activity. Involved in negative regulation of blood-brain barrier permeability; negative regulation of gene expression; and negative regulation of protein phosphorylation. Located in perinuclear region of cytoplasm.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bA335L15.1; bA335L15.1 (SH3-domain GRB2-like 2); contains SH3 domain; EEN-B1; endophilin; endophilin A1; Endophilin A1 BAR domain; endophilin I; Endophilin-1; Endophilin-A1; FLJ20276; FLJ25015; SH3 domain protein 2A; SH3 domain-containing GRB2-like protein 2; SH3-domain GRB2-like 2; SH3GL2; SH3p4; unnamed protein product
Gene Aliases: 9530001L19Rik; AI120490; AW555077; B930049H17Rik; CNSA2; EEN-B1; Een1; SH3D2A; SH3GL2; SH3P4; SH3PA
UniProt ID: (Human) Q99962, (Mouse) Q62420, (Rat) O35179
Entrez Gene ID: (Human) 6456, (Mouse) 20404, (Rat) 116743
regulation of receptor internalization
endocytosis
signal transduction
central nervous system development
negative regulation of gene expression
neuron projection development
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of MAPK cascade
synaptic vesicle endocytosis
dendrite extension
postsynaptic actin cytoskeleton organization
negative regulation of blood-brain barrier permeability
cellular response to brain-derived neurotrophic factor stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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