This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: PPGVILPMMP AKHIPPARDS RRPEPKPDKS RLFQLKNDMG LECGHKVLAK EVKKPNLRPI SKSKTDLPEE KPDATPQNPF LKSRPQV
Highest antigen sequence identity to the following orthologs: Mouse - 78%, Rat - 80%.
Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Adapter protein HOFI; adaptor protein HOFI; Factor for adipocyte differentiation 49; SH3 and PX domain-containing protein 2B; Tyrosine kinase substrate with four SH3 domains
Gene Aliases: FAD49; FTHS; HOFI; KIAA1295; SH3PXD2B; TKS4; TSK4
UniProt ID: (Human) A1X283
Entrez Gene ID: (Human) 285590