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|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A 17 amino acid peptide near the carboxy terminus of human SH3RF2.|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunocytochemistry (ICC)||20 ug/ml|
|Immunofluorescence (IF)||20 ug/ml|
|Immunohistochemistry (IHC)||10 ug/ml|
|Western Blot (WB)||1-2 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A suggested positive control is NIH-3T3 cell lysate.
PA5-21013 can be used with blocking peptide PEP-1127.
Although the SH3 domain containing ring finger 2 protein (SH3RF2) has been identified as a marker of the nucleus accumbens in the human brain, little is known about this protein. Recent yeast two-hybrid experiments have shown that SH3RF2 associates with protein phosphatase 1 (PP1) and is expressed primarily in heart and testis tissue. Recombinant SH3RF2 enhanced PP1 enzymatic activity and antagonized the ability of phopho-inhibitor-1 or -2 to inhibit PP1, suggesting that SH3RF2 may play a role working with PP1 in cardiac functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
heart protein phosphatase 1-binding protein; HEPP1, PPP1R39, RNF158; phosphatase 1 binding protein; POSH-eliminating RING protein; protein phosphatase 1 regulatory subunit 39; protein phosphatase 1, regulatory subunit 39; putative E3 ubiquitin-protein ligase SH3RF2; RING finger protein 158; SH3 domain-containing RING finger protein 2
2310046K19; 9130023G24Rik; AI452083; HEPP1; Posh2; POSHER; PPP1R39; RNF158; SH3RF2