PA1-4180 detects SHANK1a in human, rat, and mouse samples.
PA1-4180 has been successfully used in Western blot, immunofluorescence, and immunofluoresence procedures. By Western blot this antibody detects a ~212 kDa protein representing SHANK1a in rat brain lysate.
The PA1-4180 immunogen is a synthetic peptide corresponding to the C-terminal residues S(1951) G P I Y P G L F D I R S S(1964) of rat Shank1a.
Maintain at 4°C for 3 months or at -20°C for longer periods. Avoid freeze/thaw cycles.
Shank is a novel family of postsynaptic density proteins (PSD) that bind to PSD-95-associated protein GKAP. Its putative function is to act as a scaffold protein in the PSD to cross-link NMDA receptors/PSD-95 complexes and couple them to regulators of the actin cytoskeleton. Shank1a is a splice variant of Shank1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GKAP/SAPAP interacting protein; GKAP/SAPAP-interacting protein; SAPAP-interacting protein synamon; SH3 and multiple ankyrin repeat domains 1; SH3 and multiple ankyrin repeat domains protein 1; SH3/ankyrin domain gene 1; Shank1; Shank1a; Somatostatin receptor-interacting protein; SPANK-1; Spank1; SSTR-interacting protein; Sstrip; Synamon
Gene Aliases: SHANK1; Shank1a; SPANK-1; Spank1; SSTRIP; synamon