PA5-28633 targets SHANK1 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-28633 immunogen is synthetic peptide corresponding to a region within amino acids 2100 and 2161 of Human SHANK1.
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Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.
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Protein Aliases: SH3 and multiple ankyrin repeat domains 1; SH3 and multiple ankyrin repeat domains protein 1; Shank1; Somatostatin receptor-interacting protein; SSTR-interacting protein; SSTRIP; synamon
Gene Aliases: SHANK1; SPANK-1; SSTRIP; synamon