Invitrogen

SHIP1 Polyclonal Antibody

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SHIP1 Polyclonal Antibody

Product Details

PA5-17392

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunoprecipitation (IP)

1:50
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues surrounding Asp1163 of human SHIP1
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

Antigen affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10976931

Product Specific Information

It is not recommended to aliquot this antibody.

Target Information

This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: hp51CN; Inositol polyphosphate-5-phosphatase 145 kDa; Inositol polyphosphate-5-phosphatase D; Inositol polyphosphate-5-phosphatase of 145 kDa; Inositol polyphosphate-5-phosphatase, 145 kDa; inositol polyphosphate-5-phosphatase, 145kD; inositol polyphosphate-5-phosphatase, 145kDa; MGC104855; MGC142140; MGC142142; OTTHUMP00000165069; OTTHUMP00000165070; OTTHUMP00000165071; OTTHUMP00000165072; OTTHUMP00000203442; p150Ship; phosphatidylin; Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1; Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1; Phosphatidylinositol-4,5-bisphosphate 5-phosphatase; SH2 domain-containing inositol 5'-phosphatase 1; SH2 domain-containing inositol phosphatase 1; SH2 domain-containing inositol-5'-phosphatase 1; SH2-containing inositol phosphatase SHIP; SHIP-1; signaling inositol polyphosphate 5 phosphatase SIP-145; signaling inositol polyphosphate phosphatase SHIP II; SIP-145; Src homology 2 domain-containing inositol-5-phosphatase

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Gene Aliases: 7a33; hp51CN; INPP5D; p150Ship; s-SHIP; SHIP; SHIP-1; SHIP1; SIP-145

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UniProt ID: (Human) Q92835, (Mouse) Q9ES52, (Rat) P97573

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Entrez Gene ID: (Human) 3635, (Mouse) 16331, (Rat) 54259

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Function(s)
inositol-polyphosphate 5-phosphatase activity protein binding phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity SH3 domain binding phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity PTB domain binding inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity hydrolase activity inositol-4,5-bisphosphate 5-phosphatase activity phosphatidylinositol trisphosphate phosphatase activity
Process(es)
immune system process apoptotic process negative regulation of cell proliferation determination of adult lifespan negative regulation of signal transduction immunoglobulin mediated immune response dephosphorylation negative regulation of granulocyte differentiation negative regulation of B cell proliferation intracellular signal transduction positive regulation of apoptotic process negative regulation of interleukin-6 biosynthetic process positive regulation of B cell differentiation positive regulation of lymphocyte differentiation positive regulation of erythrocyte differentiation negative regulation of monocyte differentiation negative regulation of neutrophil differentiation negative regulation of osteoclast differentiation negative regulation of bone resorption phosphatidylinositol dephosphorylation negative regulation of immune response negative regulation of B cell activation phosphatidylinositol biosynthetic process phosphate-containing compound metabolic process signal transduction inositol phosphate metabolic process T cell receptor signaling pathway leukocyte migration biological_process
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