Recommended positive controls: A431, H1299.
Predicted reactivity: Mouse (96%), Rat (96%), Xenopus laevis (82%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
Protein Aliases: SETA-binding protein 1; SH3KBP1-binding protein 1
Gene Aliases: PP203; SB1; SHKBP1
UniProt ID: (Human) Q8TBC3
Entrez Gene ID: (Human) 92799
Molecular Function: scaffold/adaptor protein