Recommended positive controls: U87-MG.
Predicted reactivity: Mouse (94%), Rat (95%), Zebrafish (83%), Xenopus laevis (84%), Rabbit (94%), Sheep (95%), Rhesus Monkey (99%), Chimpanzee (99%), Bovine (95%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene encodes the cellular form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in 2 transcript variants encoding 2 different isoforms. Additional transcript variants have been described, but their biological validity has not been determined.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 14 kDa protein; CSHMT; cytoplasmic serine hydroxymethyltransferase; cytosolic; Glycine hydroxymethyltransferase; serine hydroxymethyltransferase; serine hydroxymethyltransferase 1 (soluble); Serine hydroxymethyltransferase, cytosolic; Serine methylase; SHMT
Gene Aliases: CSHMT; SHMT; SHMT1
UniProt ID: (Human) P34896
Entrez Gene ID: (Human) 6470