Peptide sequence: NIIKKESNRQ RVGLELIASE NFASRAVLEA LGSCLNNKYS EGYPGQRYYG
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Yeast: 100%; Zebrafish: 100%
This gene encodes the cellular form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in 2 transcript variants encoding 2 different isoforms. Additional transcript variants have been described, but their biological validity has not been determined.
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Protein Aliases: CSHMT; cytoplasmic serine hydroxymethyltransferase; cytosolic form; cytosolic serine hydroxymethyltransferase; Glycine hydroxymethyltransferase; MGC15229; MGC24556; serine hydroxymethyl transferase; Serine hydroxymethyltransferase 1 (soluble); serine hydroxymethyltransferase 2 (mitochondrial); Serine hydroxymethyltransferase, cytosolic; Serine methylase; SHMT; zSHMT-1
Gene Aliases: AI324848; AI385541; BOS_18774; C81125; CSHMT; LRRGT00032; MEL-32; mShmt; mshmt1; mshmt2; SHMT; SHMT1; SHMT2; zgc:66171; zgc:77524