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Invitrogen
SHMT1 Polyclonal Antibody
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Product Details
PA5-88581
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Form
Liquid
Concentration
1.77 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: FKVYQHQVVA NCRALSEALT ELGYKIVTGG SDNHLILVDL RSKGTDGGRA EKVLEACSIA CNKNTCPGDR SALRPSGLRL GTPALTSRGL LEKDFQKVAH FIHRGIELTL QIQSDTGVRA TLKEFKERLA GDKYQAAVQA LREEVESFAS LFPLPGLPDF; Positive Samples: 293T, HepG2, HT-29, K-562, A375, Mouse liver; Cellular Location: Cytoplasm
Target Information
This gene encodes the cellular form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in 2 transcript variants encoding 2 different isoforms. Additional transcript variants have been described, but their biological validity has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cytoplasmic serine hydroxymethyltransferase; Glycine hydroxymethyltransferase; L-allo-threonine/L-threonine aldolase SHMT1; MGC15229; MGC24556; serine hydroxymethyltransferase 1 (soluble); Serine hydroxymethyltransferase, cytosolic; Serine methylase; SHMT; unnamed protein product
Gene Aliases: AI324848; AI385541; C81125; CSHMT; LRRGT00032; mShmt; mshmt1; mshmt2; SHMT; SHMT1
UniProt ID: (Human) P34896, (Mouse) P50431
Entrez Gene ID: (Human) 6470, (Mouse) 20425, (Rat) 287379
translation repressor activity, nucleic acid binding
glycine hydroxymethyltransferase activity
protein binding
transferase activity
aldehyde-lyase activity
pyridoxal phosphate binding
small molecule binding
identical protein binding
protein homodimerization activity
mRNA 5'-UTR binding
serine binding
catalytic activity
L-allo-threonine aldolase activity
amino acid binding
methyltransferase
transferase
metabolite interconversion enzyme
dTMP biosynthetic process
regulation of translation
glycine metabolic process
L-serine metabolic process
L-serine catabolic process
one-carbon metabolic process
purine nucleobase biosynthetic process
negative regulation of translation
glycine biosynthetic process from serine
tetrahydrofolate interconversion
carnitine biosynthetic process
tetrahydrofolate metabolic process
folic acid metabolic process
protein homotetramerization
cellular response to tetrahydrofolate
cellular response to leukemia inhibitory factor
glycine biosynthetic process
protein tetramerization
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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