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Proteintech
SHOX2 Polyclonal Antibody
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Product Details
16366-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SHOX2 Fusion Protein Ag9156
Conjugate
Form
Liquid
Concentration
227 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
SHOX2 is a member of the homeo box family of genes that encode proteins containing a 60-amino acid residue motif that represents a DNA binding domain. Homeo box genes have been characterized extensively as transcriptional regulators involved in pattern formation in both invertebrate and vertebrate species. Several human genetic disorders are caused by aberrations in human homeo box genes. SHOX is a pseudoautosomal homeo box gene that is thought to be responsible for idiopathic short stature and implicated to play a role in the short stature phenotype of Turner syndrome patients. This gene is a member of the homeo box family of genes that encode proteins containing a 60-amino acid residue motif that represents a DNA binding domain. Homeo box genes have been characterized extensively as transcriptional regulators involved in pattern formation in both invertebrate and vertebrate species. Several human genetic disorders are caused by aberrations in human homeo box genes. SHOX is a pseudoautosomal homeo box gene that is thought to be responsible for idiopathic short stature and implicated to play a role in the short stature phenotype of Turner syndrome patients. This gene is considered to be a candidate gene for Cornelia de Lange syndrome. Alternative splicing has been observed at this locus and two variants, each encoding a distinct isoform, have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Homeobox protein Og12X; OG-12; OGI2X; Paired family homeodomain protein Prx3; Paired-related homeobox protein SHOT; Short stature homeobox protein 2; SHOX homologous gene on chromosome 3
Gene Aliases: 6330543G17Rik; OG12; OG12X; Prx3; SHOT; SHOX2
UniProt ID: (Human) O60902, (Mouse) P70390
Entrez Gene ID: (Human) 6474, (Mouse) 20429
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
osteoblast differentiation
positive regulation of mesenchymal cell proliferation
chondrocyte development
heart valve development
cardiac atrium morphogenesis
nervous system development
heart development
regulation of chondrocyte differentiation
embryonic forelimb morphogenesis
positive regulation of smoothened signaling pathway
positive regulation of transcription from RNA polymerase II promoter
embryonic digestive tract morphogenesis
positive regulation of skeletal muscle fiber development
positive regulation of axonogenesis
embryonic skeletal joint morphogenesis
cartilage development involved in endochondral bone morphogenesis
muscle tissue morphogenesis
regulation of branching morphogenesis of a nerve
chondrocyte differentiation
regulation of transcription, DNA-templated
multicellular organism development
embryonic limb morphogenesis
embryonic morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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