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Invitrogen
SHOX2 Polyclonal Antibody
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Product Details
PA5-40688
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the N-terminal of human SHOX2 (aa 2-51).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Peptide sequence: EELTAFVSKS FDQKVKEKKE AITYREVLES GPLRGAKEPT GCTEAGRDDR
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 93%
Target Information
SHOX2 is a member of the homeo box family of genes that encode proteins containing a 60-amino acid residue motif that represents a DNA binding domain. Homeo box genes have been characterized extensively as transcriptional regulators involved in pattern formation in both invertebrate and vertebrate species. Several human genetic disorders are caused by aberrations in human homeo box genes. SHOX is a pseudoautosomal homeo box gene that is thought to be responsible for idiopathic short stature and implicated to play a role in the short stature phenotype of Turner syndrome patients. This gene is a member of the homeo box family of genes that encode proteins containing a 60-amino acid residue motif that represents a DNA binding domain. Homeo box genes have been characterized extensively as transcriptional regulators involved in pattern formation in both invertebrate and vertebrate species. Several human genetic disorders are caused by aberrations in human homeo box genes. SHOX is a pseudoautosomal homeo box gene that is thought to be responsible for idiopathic short stature and implicated to play a role in the short stature phenotype of Turner syndrome patients. This gene is considered to be a candidate gene for Cornelia de Lange syndrome. Alternative splicing has been observed at this locus and two variants, each encoding a distinct isoform, have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Homeobox protein Og12X; OGI2X; Paired-related homeobox protein SHOT; short stature homeobox 2; Short stature homeobox protein 2; SHOX homologous gene on chromosome 3; unnamed protein product
Gene Aliases: OG12; OG12X; SHOT; SHOX2
UniProt ID: (Human) O60902
Entrez Gene ID: (Human) 6474
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
osteoblast differentiation
regulation of heart rate
positive regulation of mesenchymal cell proliferation
chondrocyte differentiation
chondrocyte development
sinoatrial node development
heart valve development
sinoatrial valve development
cardiac atrium morphogenesis
cardiac right atrium morphogenesis
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
smoothened signaling pathway
nervous system development
mesenchymal cell proliferation
embryonic limb morphogenesis
regulation of chondrocyte differentiation
embryonic forelimb morphogenesis
positive regulation of smoothened signaling pathway
embryonic digestive tract morphogenesis
embryonic morphogenesis
positive regulation of skeletal muscle fiber development
positive regulation of axonogenesis
embryonic skeletal joint morphogenesis
cartilage development involved in endochondral bone morphogenesis
muscle tissue morphogenesis
cardiac pacemaker cell differentiation
sinoatrial node cell development
stem cell proliferation
regulation of branching morphogenesis of a nerve
positive regulation of stem cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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