Immunogen sequence: ELKDSPSETV SSLQGPFLEE SSAFLIVDGG VRRNTAIQES DASQGKPLAS SWPLGVSGPL IEELGEQLKT TVQVSEPKGT TAVNRSNIQE RDGCQTPNN
Highest antigen sequence identity to the following orthologs: Mouse - 36%, Rat - 32%.
SHQ1 is the human homolog of yeast Shq1p, a protein that acts as an accessory factor in the assembly of H/ACA ribonucleoproteins. SHQ1 has been shown to bind the major H/ACA core protein and the pseudouridine synthase NAP57, but precedes the assembly role of NAF1 and of the other H/ACA core proteins. SHQ1 assists in the assembly of H/ACA-box ribonucleoproteins that function in the processing of ribosomal RNAs, modification of spliceosomal small nuclear RNAs, and stabilization of telomerase.
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Protein Aliases: FLJ10539; gene associated with retinoid and interferon-induced mortality 1; Protein SHQ1 homolog; SHQ1; SHQ1 homolog; Shq1p
Gene Aliases: GRIM-1; SHQ1; Shq1p
UniProt ID: (Human) Q6PI26
Entrez Gene ID: (Human) 55164