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Peptide sequence: MVIMSEFSAD PAGQGQGQQK PLRVGFYDIE RTLGKGNFAV VKLARHRVTK
Sequence homology: Cow: 100%; Dog: 93%; Guinea Pig: 85%; Horse: 100%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 90%; Rat: 100%
SIK1 may mediate the physiological effects of LKB1, including its tumor suppressor function. SIK1 is also involved in signaling by various proteins like STRAD, NUAK1, NUAK2, BRSK1, BRSK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4, and MELK that are related to AMPK. Activation of SIK1 by phosphorylation on thr322 can lead to an increase in the catalytic activity of sodium/potassium ATPase alpha subunit at the plasma membrane. This results in an increase in intracellular sodium in intact mammalian cells. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.
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Protein Aliases: myocardial SNF1-like kinase; Salt-inducible kinase 1; salt-inducible protein kinase 1; serine/threonine protein kinase; Serine/threonine-protein kinase SIK1; Serine/threonine-protein kinase SNF1-like kinase 1; Serine/threonine-protein kinase SNF1LK; SIK-1; SNF1-like kinase
Gene Aliases: EIEE30; MSK; SIK; SIK1; SNF1LK
UniProt ID: (Human) P57059
Entrez Gene ID: (Human) 150094
Molecular Function: non-receptor serine/threonine protein kinase