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|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A 16 amino acid synthetic peptide near the center of human SIK2|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunocytochemistry (ICC)||2.5 ug/ml|
|Immunofluorescence (IF)||2.5 ug/ml|
|Western Blot (WB)||1 ug/mL|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A suggested positive control is SW480 cell lysate.
PA5-34339 can be used with blocking peptide PEP-1254.
Salt-inducible kinase 2 (SIK2), like its closely related homolog SIK1, belongs AMPK subfamily of the Ser/Thr protein kinase family and negatively regulates CRE-binding protein (CREB) activity by phosphorylating the CREB-specific coactivator transducer of regulated CREB activity (TORC). SIK2 is thought to be part of a signaling cascade that regulates the expression and activity of the insulin-induced genes PGC-1 alpha and UCP-1 in brown adipocytes, impairment of which has been implicated in obesity and insulin resistance in human and animal models. SIK2 has also been reported as a key regulator for neuronal survival after ischemia, suppressing CREB-mediated gene expression after oxygen-glucose deprivation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
LOH11CR1I; QIK; qin-induced kinase; salt induceable kinase 2; salt-inducible kinase 2; Salt-inducible protein kinase 2; salt-inducible serine/threonine kinase 2; Serine; serine/threonine-protein kinase SIK2; serine/threonine-protein kinase SNF1-like kinase 2; SIK-2; SIK2; SNF1-like kinase 2; SNF1LK2; threonine-protein kinase SNF1-like kinase 2
G630080D20Rik; KIAA0781; LOH11CR1I; QIK; RGD1559698; SIK-2; SIK2; SNF1LK2