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Proteintech
SIM2 Polyclonal Antibody
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Product Details
21069-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SIM2 Fusion Protein Ag15204 (342-525 aa encoded by BC110444)
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LSLEQVSTA KSQDSWRTAL STSQETRKLV KPKNTKMKTK LRTNPYPPQQ YSSFQMDKLE CGQLGNWRAS PPASAAAPPE LQPHSESSDL LYTPSYSLPF SYHYGHFPLD SHVFSSKKPM LPAKFGQPQG SPCEVARFFL STLPASGECQ WHYANPLVPS SSSPAKNPPE PPANTARHSL VPSYE (342-525 aa encoded by BC110444)
Target Information
This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: bHLHe15; Class E basic helix-loop-helix protein 15; human SIM2; mSIM; SIM transcription factor; single-minded 2; single-minded family bHLH transcription factor 2; Single-minded homolog 2; transcription factor SIM2; unnamed protein product
Gene Aliases: BHLHE15; HMC13F06; HMC29C01; SIM; SIM2
UniProt ID: (Human) Q14190, (Mouse) Q61079
Entrez Gene ID: (Human) 6493, (Rat) 304071, (Mouse) 20465
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein heterodimerization activity
protein dimerization activity
signal transducer activity
basic helix-loop-helix transcription factor
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
nervous system development
embryonic pattern specification
cell differentiation
lung development
negative regulation of transcription, DNA-templated
system development
transcription, DNA-templated
signal transduction
transcription from RNA polymerase II promoter
multicellular organism development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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