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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 115 and 355 of Human SIN3B|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-30680 targets SIN3B in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-30680 immunogen is recombinant fragment corresponding to a region within amino acids 115 and 355 of Human SIN3B.
Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
histone deacetylase complex subunit Sin3b; paired amphipathic helix protein Sin3b; SIN3 homolog B; SIN3 homolog B, transcriptional regulator; SIN3 transcription regulator homolog B; SIN3B; transcription regulator; transcriptional corepressor Sin3b; transcriptional regulator