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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide between amino acids 300-355 of the human SIRT6 protein.|
|Purification||Antigen affinity chromatography|
|Storage buffer||tris citrate, pH 7-8|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Western Blot (WB)||2 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-16957 is specific for the ~39 kDa SIRT6 protein.
A higher molecular weight band at ~59 kDa may be seen with lower dilutions such as 2 ug/ml.
Suggested positive control: antigen standard for SIRT6 (transient overexpression lysate), Hela whole cell extract.
Sirtuins regulate epigenetic gene silencing. SIRT6 (Mono-ADP-ribosyltransferase sirtuin-6), a mouse Sir2 homolog, is a chromatin-associated nuclear ADP-ribosyltransferase protein. It appears to be involved in DNA repair and may also play a role in human ageing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Mono-ADP-ribosyltransferase sirtuin-6; regulatory protein SIR2 homolog 6; Silent information regulator 2-like protein 6.; SIR2-like protein 6; sir2-related protein type 6; sirtuin type 6