Invitrogen

SIRT6 Polyclonal Antibody

View all (24) SIRT6 antibodies

Questions & Answers

Questions & Answers

Product Image Gallery

SIRT6 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry (Paraffin) analysis of SIRT6 in paraffin-embedded mouse brain tissue using SIRT6 polyclonal Antibody (Product # PA5-118404).

SIRT6 Antibody in Western Blot (WB) — Western Blot analysis of SIRT6 in mouse thymus lysates using SIRT6 polyclonal Antibody (Product # PA5-118404).

SIRT6 Antibody in Flow Cytometry (Flow) — Flow Cytometry analysis of SIRT6 in Hela cells. The cells were fixed, permeabilized and stained with SIRT6 polyclonal Antibody (Product # PA5-118404) at a dilution of 1:50 (blue). Alexa Fluor 488-conjugated Goat anti rabbit IgG was used as the secondary antibody. Unlabelled control (cells without incubation with primary antibody; red).

Product Details

PA5-118404

Applications	Tested Dilution	Publications
Western Blot (WB)	1:1,000-1:2,000	-
Immunohistochemistry (Paraffin) (IHC (P))	1:50-1:200	-
Flow Cytometry (Flow)	1:50-1:100	-

Product Specifications
Species Reactivity	Human, Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Synthetic peptide within N-terminal human SIRT6 View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	1 mg/mL
Purification	Affinity chromatography
Storage buffer	PBS, pH 7.4, with 40% glycerol, 0.2% BSA
Contains	0.05% sodium azide
Storage conditions	Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Target Information

Sirtuins regulate epigenetic gene silencing. SIRT6 (Mono-ADP-ribosyltransferase sirtuin-6), a mouse Sir2 homolog, is a chromatin-associated nuclear ADP-ribosyltransferase protein. It appears to be involved in DNA repair and may also play a role in human aging.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?

Let us know so we can reference it here.

Cite this product

Bioinformatics

Protein Aliases: NAD-dependent deacetylase sirtuin-6; NAD-dependent protein deacetylase sirtuin-6; Regulatory protein SIR2 homolog 6; SIR2; SIR2 like 6; SIR2-like protein 6; sir2-related protein type 6; sirtuin type 6

Gene Aliases: 2810449N18Rik; AI043036; SIR2L6; SIRT6

UniProt ID: (Human) Q8N6T7, (Mouse) P59941

Entrez Gene ID: (Human) 51548, (Mouse) 50721

post-embryonic cardiac muscle cell growth involved in heart morphogenesis base-excision repair protein ADP-ribosylation negative regulation of cell proliferation regulation of double-strand break repair via homologous recombination protein destabilization response to nutrient levels glucose homeostasis negative regulation of glycolytic process negative regulation of transcription, DNA-templated negative regulation of glucose import positive regulation of fibroblast proliferation histone H3-K9 modification histone H3-K9 deacetylation positive regulation of stem cell proliferation

Process(es)

chromatin binding transcription corepressor activity NAD+ ADP-ribosyltransferase activity NAD(P)+-protein-arginine ADP-ribosyltransferase activity protein binding zinc ion binding NAD-dependent histone deacetylase activity NAD-dependent protein deacetylase activity NAD-dependent histone deacetylase activity (H3-K9 specific) NAD+ binding histone deacetylase activity protein-N-terminal asparagine amidohydrolase activity UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity hydrolase activity iprodione amidohydrolase activity (3,5-dichlorophenylurea)acetate amidohydrolase activity protein deacetylase activity 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity didemethylisoproturon amidohydrolase activity N-isopropylacetanilide amidohydrolase activity N-cyclohexylformamide amidohydrolase activity isonicotinic acid hydrazide hydrolase activity cis-aconitamide amidase activity gamma-N-formylaminovinylacetate hydrolase activity N2-acetyl-L-lysine deacetylase activity O-succinylbenzoate synthase activity indoleacetamide hydrolase activity N-acetylcitrulline deacetylase activity metal ion binding N-acetylgalactosamine-6-phosphate deacetylase activity diacetylchitobiose deacetylase activity chitooligosaccharide deacetylase activity