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Invitrogen

SIX1 Polyclonal Antibody

View all (10) SIX1 antibodies

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SIX1 Polyclonal Antibody

Product Details

PA5-101643

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human SIX1(Accession Q15475), corresponding to amino acid residues V111-T161.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2851077

Product Specific Information

Antibody detects endogenous levels of total SIX1.

Target Information

The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: sine oculis homeobox homolog 1; sine oculis-related homeobox 1 homolog; six1; unnamed protein product

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Gene Aliases: BOS3; DFNA23; TIP39

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UniProt ID: (Human) Q15475, (Mouse) Q62231

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Entrez Gene ID: (Human) 6495, (Mouse) 20471

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription coactivator binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding sequence-specific DNA binding sequence-specific double-stranded DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter metanephros development ureteric bud development branching involved in ureteric bud morphogenesis cell fate specification organ induction kidney development outflow tract morphogenesis regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter Notch signaling pathway specification of segmental identity, maxillary segment pattern specification process skeletal muscle tissue development sensory perception of sound regulation of synaptic growth at neuromuscular junction gene expression regulation of gene expression neural crest cell differentiation regulation of skeletal muscle satellite cell proliferation facial nerve morphogenesis neurogenesis epithelial cell differentiation thyroid gland development olfactory placode formation regulation of protein localization protein localization to nucleus aorta morphogenesis inner ear morphogenesis middle ear morphogenesis negative regulation of apoptotic process negative regulation of neuron apoptotic process tongue development regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter thymus development neuron fate specification generation of neurons embryonic cranial skeleton morphogenesis embryonic skeletal system morphogenesis skeletal system morphogenesis mesenchymal cell differentiation inner ear development regulation of epithelial cell proliferation myoblast migration pharyngeal system development myotome development fungiform papilla morphogenesis trigeminal ganglion development otic vesicle development kidney mesenchyme development metanephric mesenchyme development nephron epithelium morphogenesis regulation of branch elongation involved in ureteric bud branching positive regulation of ureteric bud formation mesonephric tubule formation ureter smooth muscle cell differentiation positive regulation of secondary heart field cardioblast proliferation endothelin receptor signaling pathway cochlea morphogenesis regulation of branching involved in ureteric bud morphogenesis positive regulation of branching involved in ureteric bud morphogenesis positive regulation of brown fat cell differentiation cellular response to 3,3',5-triiodo-L-thyronine positive regulation of mesenchymal cell proliferation involved in ureter development regulation of skeletal muscle cell differentiation
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