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Invitrogen
SIX2 Polyclonal Antibody
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FIGURE: 1 / 2
SIX2 Antibody (PA5-97149) in WB
Western blot analysis of SIX2 in extracts of various cell lines. Samples were incubated with SIX2 Polyclonal antibody (Product # PA5-97149) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Product Details
PA5-97149
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 120-174 of human SIX2 (NP_0586283)
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Amount
40 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SIWDGEETSY CFKEKSRSVL REWYAHNPYP SPREKRELAE ATGLTTTQVS NWFKN
Positive Samples: Rat kidney; Cellular Location: Nucleus
Target Information
This gene is a member of the vertebrate gene family which encode proteins homologous to the Drosophila 'sine oculis' homeobox protein. SIX2 is a transcription factor which, like other members of this gene family, may be involved in limb or eye development.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Homeobox protein SIX2; Sine oculis homeobox homolog 2; sine oculis-related homeobox 2 homolog; SIX2
Gene Aliases: SIX2
UniProt ID: (Human) Q9NPC8
Entrez Gene ID: (Human) 10736, (Rat) 366542
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
macromolecular complex binding
sequence-specific double-stranded DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor binding
protein complex binding
homeodomain transcription factor
metanephros development
kidney development
chondrocyte differentiation
mesenchymal to epithelial transition involved in metanephros morphogenesis
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
protein import into nucleus
mesodermal cell fate specification
cell proliferation
anatomical structure morphogenesis
anterior/posterior axis specification
cell migration
regulation of ossification
epithelial cell differentiation
negative regulation of epithelial cell differentiation
regulation of chondrocyte differentiation
middle ear morphogenesis
positive regulation of transcription from RNA polymerase II promoter
embryonic digestive tract morphogenesis
embryonic cranial skeleton morphogenesis
embryonic skeletal system morphogenesis
nephron development
nephron morphogenesis
mesenchymal stem cell maintenance involved in nephron morphogenesis
condensed mesenchymal cell proliferation
mesenchymal cell differentiation involved in kidney development
regulation of branching involved in ureteric bud morphogenesis
mesenchymal stem cell proliferation
positive regulation of chondrocyte proliferation
transcription from RNA polymerase II promoter
negative regulation of cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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