Proteintech

SLC11A2 Polyclonal Antibody

View all (7) SLC11A2 antibodies

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SLC11A2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded mouse brain tissue slide using 20507-1-AP (SLC11A2 antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

SLC11A2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded mouse brain tissue slide using 20507-1-AP (SLC11A2 antibody) at dilution of 1:200 (under 10x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

SLC11A2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human pancreas tissue slide using 20507-1-AP (SLC11A2 antibody) at dilution of 1:200 (under 40x lens).

SLC11A2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human pancreas tissue slide using 20507-1-AP (SLC11A2 antibody) at dilution of 1:200 (under 10x lens).

SLC11A2 Antibody in Western Blot (WB) — Human testis tissue were subjected to SDS PAGE followed by western blot with 20507-1-AP (SLC11A2 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

SLC11A2 Antibody in Western Blot (WB) — Mouse thymus tissue were subjected to SDS PAGE followed by western blot with 20507-1-AP (SLC11A2 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

SLC11A2 Antibody in Western Blot (WB) — Human brain tissue were subjected to SDS PAGE followed by western blot with 20507-1-AP (SLC11A2 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

SLC11A2 Antibody in Western Blot (WB) — COLO 320 cells were subjected to SDS PAGE followed by western blot with 20507-1-AP (SLC11A2 antibody) at dilution of 1:2500 incubated at room temperature for 1.5 hours.

SLC11A2 Antibody in Western Blot (WB) — Rat kidney tissue were subjected to SDS PAGE followed by western blot with 20507-1-AP (DMT1 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

SLC11A2 Antibody in Western Blot (WB) — Neuro-2a cells were subjected to SDS PAGE followed by western blot with 20507-1-AP (SLC11A2 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

SLC11A2 Antibody in Western Blot (WB) — SH-SY5Y cells were subjected to SDS PAGE followed by western blot with 20507-1-AP (SLC11A2 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

SLC11A2 Antibody in Western Blot (WB) — HEK-293 cells were subjected to SDS PAGE followed by western blot with 20507-1-AP (SLC11A2 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

SLC11A2 Antibody in Western Blot (WB) — HuH-7 cells were subjected to SDS PAGE followed by western blot with 20507-1-AP (DMT1 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

Product Details

Tested Applications

Dilution

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Western Blot (WB)

1:500-1:1000

Published Applications

Western Blot (WB)

See 5 publications below

Miscellaneous PubMed (MISC)

See 1 publication below

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host / Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SLC11A2 Fusion Protein Ag14314

Conjugate

Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Product Specific Information

This antibody detected various forms of SLC11A2 of 45-100 kDa.

Target Information

This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: DCT1; Divalent cation transporter 1; Divalent metal transporter 1; DMT 1; DMT-1; DMT1; microcytic anemia, viable anaemia; Natural resistance-associated macrophage protein 2; NRAMP 2; NRAMP2; SLC11A2; solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2; Solute carrier family 11 member 2; Solute carrier family 11 member 2 (natural resistance-associated macrophage protein 2)

Gene Aliases: AHMIO1; DCT1; DMT1; mk; NRAMP2; OK/SW-cl.20; SLC11A2; van

UniProt ID: (Human) P49281, (Mouse) P49282, (Rat) O54902

Entrez Gene ID: (Human) 4891, (Mouse) 18174, (Rat) 25715

Molecular Function: cation transporter transporter

heme biosynthetic process cobalt ion transport copper ion transport manganese ion transport cellular iron ion homeostasis learning or memory response to iron ion ferrous iron transport lead ion transport transferrin transport copper ion transmembrane transport dendrite morphogenesis erythrocyte development multicellular organismal iron ion homeostasis cadmium ion transmembrane transport ferrous iron import manganese ion transmembrane transport hydrogen ion transmembrane transport ferrous iron transmembrane transport transition metal ion transport porphyrin-containing compound metabolic process porphyrin-containing compound biosynthetic process transport ion transport iron ion transport cellular copper ion homeostasis activation of cysteine-type endopeptidase activity involved in apoptotic process response to manganese ion nickel cation transport vanadium ion transport proton transport cellular response to oxidative stress iron ion transmembrane transport nickel cation transmembrane transport iron ion homeostasis zinc II ion transmembrane transport cation transmembrane transport copper ion import into cell response to hypoxia detection of oxygen response to lead ion response to cadmium ion cellular response to iron ion cellular response to tumor necrosis factor cellular response to hypoxia

Process(es)

copper ion transmembrane transporter activity iron ion transmembrane transporter activity manganese ion transmembrane transporter activity protein binding hydrogen ion transmembrane transporter activity cadmium ion transmembrane transporter activity cobalt ion transmembrane transporter activity ferrous iron transmembrane transporter activity lead ion transmembrane transporter activity solute:proton symporter activity ferrous iron uptake transmembrane transporter activity transferrin transmembrane transporter activity cadmium ion binding transition metal ion transmembrane transporter activity transporter activity iron ion binding copper ion binding zinc ion binding nickel cation transmembrane transporter activity vanadium ion transmembrane transporter activity nickel cation binding inorganic cation transmembrane transporter activity manganese ion binding cobalt ion binding zinc ion transmembrane transporter activity calcium ion transmembrane transporter activity chromium ion transmembrane transporter activity