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Proteintech

SLC11A2 Polyclonal Antibody

5 References
View all (10) SLC11A2 antibodies
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Product Details

20507-1-AP

Applications Tested Dilution Publications

Western Blot (WB)

 1:500-1:1,000 View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

 1:50-1:500 -
Product Specifications

Species Reactivity

 Human, Mouse, Rat

Published species

 Human, Mouse

Host/Isotype

 Rabbit / IgG

Class

 Polyclonal

Type

 Antibody

Immunogen

SLC11A2 Fusion Protein Ag14314 (1-80 aa encoded by BC002592)

Conjugate

 Unconjugated

Form

 Liquid

Concentration

 0.27 mg/mL

Purification

 Antigen affinity chromatography

Storage buffer

 PBS, pH 7.3, with 50% glycerol

Contains

 0.02% sodium azide

Storage conditions

 -20°C

Product Specific Information

This antibody detected various forms of SLC11A2 of 45-100 kDa.

Immunogen sequence: MVLGPEQKM SDDSVSGDHG ESASLGNINP AYSNPSLSQS PGDSEEYFAT YFNEKISIPE EEYSCFSFRK LWAFTGPGFL M (1-80 aa encoded by BC002592)

Target Information

This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Dct-1; Divalent cation transporter 1; Divalent metal transporter 1; DMT-1; microcytic anemia, viable anaemia; Natural resistance-associated macrophage protein 2; NRAMP 2; solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2; Solute carrier family 11 member 2; Solute carrier family 11 member 2 (natural resistance-associated macrophage protein 2)

Gene Aliases: AHMIO1; DCT1; DMT1; mk; NRAMP2; OK/SW-cl.20; SLC11A2; van

UniProt ID: (Human) P49281, (Mouse) P49282, (Rat) O54902

Entrez Gene ID: (Human) 4891, (Mouse) 18174, (Rat) 25715

Molecular Function: secondary carrier transporter

Function(s)
heme biosynthetic process cobalt ion transport copper ion transport manganese ion transport cellular iron ion homeostasis learning or memory response to iron ion ferrous iron transport lead ion transport transferrin transport copper ion transmembrane transport dendrite morphogenesis erythrocyte development multicellular organismal iron ion homeostasis cadmium ion transmembrane transport ferrous iron import manganese ion transmembrane transport hydrogen ion transmembrane transport ferrous iron transmembrane transport transition metal ion transport porphyrin-containing compound metabolic process porphyrin-containing compound biosynthetic process transport ion transport iron ion transport cellular copper ion homeostasis activation of cysteine-type endopeptidase activity involved in apoptotic process response to manganese ion nickel cation transport vanadium ion transport proton transport cellular response to oxidative stress iron ion transmembrane transport nickel cation transmembrane transport iron ion homeostasis zinc II ion transmembrane transport cation transmembrane transport copper ion import into cell response to hypoxia detection of oxygen response to lead ion response to cadmium ion cellular response to iron ion cellular response to tumor necrosis factor cellular response to hypoxia
Process(es)
copper ion transmembrane transporter activity iron ion transmembrane transporter activity manganese ion transmembrane transporter activity protein binding hydrogen ion transmembrane transporter activity cadmium ion transmembrane transporter activity cobalt ion transmembrane transporter activity ferrous iron transmembrane transporter activity lead ion transmembrane transporter activity solute:proton symporter activity ferrous iron uptake transmembrane transporter activity transferrin transmembrane transporter activity cadmium ion binding transition metal ion transmembrane transporter activity transporter activity iron ion binding copper ion binding zinc ion binding nickel cation transmembrane transporter activity vanadium ion transmembrane transporter activity nickel cation binding inorganic cation transmembrane transporter activity manganese ion binding cobalt ion binding zinc ion transmembrane transporter activity calcium ion transmembrane transporter activity chromium ion transmembrane transporter activity

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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