Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Invitrogen
FIGURE: 1 / 2
Positive Samples: Mouse brain, Rat brain; Cellular Location: Mitochondrion inner membrane, Multi-pass membrane protein
Immunogen sequence: GHQKSTTVSH EMSGLNWKPF VYGGLASIVA EFGTFPVDLT KTRLQVQGQS IDARFKEIKY RGMFHALFRI CKEEGVLALY SGIAPALLRQ ASYGTIKIGI YQSLKRLFVE RLEDETLLIN MICGVVSGVI SSTIANPTDV LKIRMQAQGS LFQGSMIGSF IDIYQQEGTR GLWRGV
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is widely expressed in many tissues with the greatest abundance in brain and testis. The gene product has an N-terminal hydrophobic domain that is not present in other UCPs. Two splice variants have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BMCP-1; Brain mitochondrial carrier protein 1; Mitochondrial uncoupling protein 5; solute carrier family 25 (mitochondrial carrier, brain), member 14; Solute carrier family 25 member 14; UCP 5
Gene Aliases: BMCP1; SLC25A14; UCP5; UCP5L; UCP5S; UNQ791/PRO1682
UniProt ID: (Human) O95258, (Mouse) Q9Z2B2
Entrez Gene ID: (Human) 9016, (Mouse) 20523, (Rat) 85263
Molecular Function: transporter secondary carrier transporter
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support