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Invitrogen
SLC25A36 Polyclonal Antibody
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Product Details
PA5-113281
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Solute carrier family 25 member 36 protein (58-110AA)
Conjugate
Form
Liquid
Concentration
3.3 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The SLC25A36 gene is part of the solute carrier family 25 (SLC25), which encodes mitochondrial transport proteins. SLC25A36 specifically functions as a transporter of pyrimidine nucleotides, including deoxynucleotide triphosphates, across the inner mitochondrial membrane. This transport is essential for maintaining mitochondrial DNA synthesis and repair, as well as for the proper functioning of mitochondrial ribonucleotide reductase. The SLC25A36 protein exhibits a characteristic transmembrane structure with six transmembrane helices and a central substrate-binding site. It operates via a mechanism involving substrate binding, conformational changes, and alternating access to the substrate-binding site from either side of the membrane. Dysregulation or mutations in SLC25A36 can lead to mitochondrial dysfunction and are associated with various metabolic disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: solute carrier family 25 (pyrimidine nucleotide carrier ), member 36; solute carrier family 25 (pyrimidine nucleotide carrier), member 36; Solute carrier family 25 member 36; solute carrier family 25, member 36
Gene Aliases: PNC2; SLC25A36
UniProt ID: (Human) Q96CQ1
Entrez Gene ID: (Human) 55186
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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