The antibody detects endogenous levels of total FATP1 / SLC27A1 protein.
The protein involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids .Highest levels of expression are detected in muscle and adipose tissue small, intermediate levels in small intestine, and barely detectable in liver.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ACSVL5; FATP-1; FATP1; fatty acid transport protein 1; Long-chain fatty acid transport protein 1; solute carrier family 27 (fatty acid transporter), member 1; Solute carrier family 27 member 1
Gene Aliases: ACSVL5; FATP; FATP-1; FATP1; SLC27A1
UniProt ID: (Human) Q6PCB7
Entrez Gene ID: (Human) 376497
Molecular Function: ligase