Display Info:
cookie.CK_ISO_CODE.value:us
cookie.CK_LANG_CODE.value:en
cookie.CK_DISPLAY_TYPE.value:
pageContext.request:org.apache.struts2.dispatcher.StrutsRequestWrapper@794d98ec
Request attributes: pageContext.request.scheme:http(not used)
syndicationProtocol:https
syndicationExtensionPrefix:.secure
syndicationDisplayType:
      View (5) other SLC7A11 antibodies

      Invitrogen

      SLC7A11 Polyclonal Antibody

      References Icon 2 References
      DataSheets Icon

      Data Sheets
      Create Citation Icon

      Create Citation
      Tech Support Icon

      Tech Support

       Tech Support Icon

      Tech Support

      Catalog #:PA1-16893

      Label Icon Check your price
       

      Quantity:

      BulkOrderIcon Bulk order
      Add To Cart
      Create your first list
      What is a shared list?

      Guarantee Icon Performance Guarantee

      Product Details

      TESTED APPLICATIONS DILUTION
      Flow Cytometry (Flow) 2-3 µg/ml
      Immunocytochemistry (ICC) 1:100-1:1000
      Immunofluorescence (IF) 1:100-1:1000
      Immunohistochemistry (IHC) 5 µ/gml
      Immunohistochemistry (Paraffin) (IHC (P)) 5 µg/ml
      Western Blot (WB) 1:1000
      PUBLISHED APPLICATIONS
      Western Blot (WB) See 1 publications below
      Immunohistochemistry (IHC) See 1 publications below
      Tested Species reactivity Human, Mouse, Rat
      Published species reactivity Human
      Host / Isotype Rabbit / IgG
      Class Polyclonal
      Type Antibody
      Immunogen Synthetic peptide between amino acid 1-50 of the human XCT protein.
      Conjugate Unconjugated
      Form Liquid
      Concentration 1 mg/ml
      Purification Antigen affinity chromatography
      Storage buffer PBS
      Contains 0.02% sodium azide
      Storage conditions Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
      RRID AB_2286208

      Product Specific Information

      This antibody is not recommended for Immunoprecipitation.

      Permeablization is recommended prior to performing Flow analysis.

      Suggested positive control: antigen standard for SLC7A11 (transient overexpression lysate), human stomach protein or stomach tissue lysate.

      Background/Target Information

      Mammalian amino acid transport systems consist of a large variety of transporters. The amino acid transporter, cystine/glutamic acid transporter xCT, for system xc has been proposed to be responsible for the cystine transport through the plasma membrane. System xc mediates an amino acid exchange and prefers cystine and glutamate as its substrates. The transporter designated as xCT requires 4F2 heavy chain (4F2hc:CD98) for its functional expression, and belongs to the family of amino acid transporters that associates with the type II membrane glycoproteins such as 4F2hc.

      In brain, it has been proposed that system xc is up-regulated in glial cells upon oxidative stress and plays an essential roles to protect neurons against oxidative stress. Recent studies have implicated xCT as a gateway that Kaposi's sarcoma herpesvirus (KSHV) uses to enter cells.

      For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

      References (2)

      References Icon

      Have you cited this antibody in a publication? so we can reference it in this datasheet.

      Bioinformatics

      Protein Aliases: Amino acid transport system xc-; Amino acid transport system xc-xCT antibody; Calcium channel blocker resistance protein CCBR1; Calcium channel blocker resistance protein CCBR1 antibody.; cysteine/glutamate transporter; Cysteine/glutamate transporter antibody; Cystine/glutamate transporter; sodium independent anionic amino acid transport system; solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11; solute carrier family 7 (cationic amino acid transporter, y+ system), member 11; Solute carrier family 7 member 11; solute carrier family 7, (cationic amino acid transporter, y+ system) member 11; xCT

      Gene Aliases: 9930009M05Rik; AI451155; CCBR1; SLC7A11; sut; xCT

      UniProt ID: (Human) Q9UPY5, (Mouse) Q9WTR6

      Entrez Gene ID: (Human) 23657, (Mouse) 26570, (Rat) 310392

      Molecular Function: amino acid transporter transporter

      Suggested Secondary Antibodies

      Documents

      Material safety data sheets (MSDS)

      Performance Guarantee

      If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*

      We’re here to help

      Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

      Display Info:
      cookie.CK_ISO_CODE.value:us
      cookie.CK_LANG_CODE.value:en
      cookie.CK_DISPLAY_TYPE.value:
      pageContext.request.scheme:http(not used)
      syndicationProtocol:https
      syndicationExtensionPrefix:.secure
      syndicationDisplayType: