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Invitrogen
SMARCB1 Recombinant Rabbit Monoclonal Antibody (8A7O2)
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Product Details
MA5-57894
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
8A7O2
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human SMARCB1/SNF5 (NP_003064.2).
Conjugate
Form
Liquid
Concentration
1.86 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Product Specific Information
Immunogen sequence: LWRRLATVEE RKKIVASSHG KKTKPNTKDH GYTTLATSVT LLKASEVEEI LDGNDEKYKA VSISTEPPTY LREQKAKRNS QWVPTLPNSS HHLDAVPCST T
Target Information
The SWI-SNF complex is involved in the activation of transcription via the remodeling of nucleosome structure in an ATP-dependent manner. Brm (also designated SNF2alpha) and Brg-1 (also designated SNF2beta) are the ATPase subunits of the mammalian SWI-SNF complex. Brm, Brg-1, Ini1 (integrase interactor 1, also designated SNF5), BAF155 (also designated SRG3) and BAF170 are thought to comprise the functional core of the SWI-SNF complex. Addition of Ini1, BAF155 and BAF170 to Brg-1 appears to increase remodeling activity. Other complex subunits are thought to play regulatory roles. hSNF2L and hSNF2H both appear to be homologs of Drosophila ISWI, a Brm related ATPase that is present in chromatin remodeling complexes other than SWI/SNF, including the NURF (nucleosome remodeling factor).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BAF47; BRG1-associated factor 47; BRG1-associated factor 47 (BAF47); hSNF5; Ini1; Ini1b; INI1D; INI1E; INI1F; Integrase interactor 1 protein; malignant rhabdoid tumor suppressor; mSNF5; protein phosphatase 1, regulatory subunit 144; SMARCB1; SNF5 homolog; Sucrose nonfermenting yeast homolog like 1; sucrose nonfermenting, yeast, homolog-like 1; SWI/SNF related matrix-associated actin dependent regulator of chromatin, subfamily b, member 1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; SWI/SNF-related matrix-associated protein; SWI10; Transcription factor TYE4; Transcription regulatory protein SNF5; TYE4; unnamed protein product
Gene Aliases: AU020204; BAF47; CSS3; hSNFS; INI-1; INI1; MRD15; PPP1R144; RDT; RTPS1; Sfh1p; SMARCB1; SNF5; SNF5/INI1; SNF5L1; Snr1; SWNTS1
UniProt ID: (Human) Q12824, (Mouse) Q9Z0H3
Entrez Gene ID: (Human) 6598, (Mouse) 20587, (Rat) 361825
RNA polymerase I CORE element sequence-specific DNA binding
p53 binding
DNA binding
transcription coactivator activity
protein binding
Tat protein binding
nucleosomal DNA binding
identical protein binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
DNA metabolism protein
RNA polymerase I preinitiation complex assembly
blastocyst development
blastocyst hatching
chromatin organization
nucleosome disassembly
chromatin remodeling
regulation of transcription from RNA polymerase II promoter
nervous system development
negative regulation of cell proliferation
DNA integration
regulation of mitotic metaphase/anaphase transition
single stranded viral RNA replication via double stranded DNA intermediate
positive regulation by host of viral transcription
positive regulation of T cell differentiation
positive regulation of cell differentiation
positive regulation of myoblast differentiation
positive regulation of gene expression, epigenetic
positive regulation of transcription from RNA polymerase II promoter
regulation of G0 to G1 transition
hepatocyte differentiation
positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
positive regulation of stem cell population maintenance
positive regulation of glucose mediated signaling pathway
regulation of G1/S transition of mitotic cell cycle
positive regulation of double-strand break repair
regulation of nucleotide-excision repair
DNA repair
transcription, DNA-templated
regulation of transcription, DNA-templated
cell cycle
chromatin modification
cell differentiation
ATP-dependent chromatin remodeling
mitotic cell cycle phase transition
positive regulation of sequence-specific DNA binding transcription factor activity
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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