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Invitrogen
SMC1B Polyclonal Antibody
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Product Details
PA5-22199
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the N-terminus region of human SMC1B. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11153262
Product Specific Information
Recommended positive controls: A431, H1299, HeLa, HepG2, Molt-4, Raji.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The SMC1B gene encodes a meiosis-specific subunit of the cohesin complex, which is essential for proper chromosome segregation during meiosis. It plays a critical role in sister chromatid cohesion and DNA recombination. The SMC1B protein, also known as SMC1 beta, forms a heterodimer with SMC3, which is necessary for the formation of the cohesin complex that holds sister chromatids together until anaphase. Studies have demonstrated that SMC1B is required for the activation of the spindle assembly checkpoint (SAC) during oocyte meiosis. The loss of SMC1B function leads to improper chromosome alignment and segregation, resulting in infertility due to meiotic arrest. Furthermore, the gene is expressed exclusively during meiosis, and mutations or deletions within SMC1B can cause sterility due to disruptions in meiotic progression.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bK268H5; bK268H5.5; mitosis-specific chromosome segregation protein like protein beta; RP1-102D24.3; SMC protein 1B; SMC-1-beta; SMC-1B; SMC1 (structural maintenance of chromosomes 1, yeast)-like 1; SMC1 structural maintenance of chromosomes 1-like 2; Structural maintenance of chromosomes protein 1B
Gene Aliases: SMC1B; SMC1BETA; SMC1L2
UniProt ID: (Human) Q8NDV3
Entrez Gene ID: (Human) 27127
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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