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Proteintech
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Sequence of this protein is as follows: LTAPLLANTT EDKPSKDDFQ TAQLLALVLE LLTFCVEHHT YHIKNYIINK DILRRVLVLM ASKHAFLALC ALRFKRKIIG LKDEFYNRYI MKSFLFEPVV KAFLNNGSRY NLMNSAIIEM FEFIRVEDIK SLTAHVIENY WKALEDVDYV QTFKGLKLRF EQQRERQDNP KLDSMRSILR NHRYRRDART LEDEEEMWFN TDEDDMEDGE AVVSPSDKTK NDDDIMDPIS KFMERKKLKE SEEKEVLLKT NLSGRQSPSF KLSLSSGTKT NLTSQSSTTN LPGSPGSPGS PGSPGSPGSV PKNTSQTAAI TTKGGLVGLV DYPDDDEDDD EDEDKEDTLP LSKKAKFDS
Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Serine/threonine-protein phosphatase 4 regulatory subunit 3A; SMEK homolog 1; SMEK homolog 1, suppressor of mek1; unnamed protein product
Gene Aliases: FLFL1; KIAA2010; MSTP033; PP4R3; PP4R3A; PPP4R3A; SMEK1; smk-1; smk1
UniProt ID: (Human) Q6IN85
Entrez Gene ID: (Human) 55671
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