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SMPD3 Antibody (PA5-117447) in WB
Western Blot using SMPD3 Polyclonal Antibody (Product # PA5-117447). Various tissue extracts (50 µg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with SMPD3 Polyclonal Antibody (Product # PA5-117447) diluted at 1:1,000. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
Product Details
PA5-117447
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human NSMase2. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.9 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2902077
Product Specific Information
Centrifuge briefly prior to opening.
Target Information
Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Neutral sphingomyelinase 2; Neutral sphingomyelinase II; nSMase-2; Sphingomyelin phosphodiesterase 3; sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
Gene Aliases: 4631433G07Rik; AI427456; AW537966; fro; NSMASE2; SMPD3
UniProt ID: (Human) Q9NY59, (Mouse) Q9JJY3
Entrez Gene ID: (Human) 55512, (Mouse) 58994
hematopoietic progenitor cell differentiation
sphingomyelin catabolic process
glycosphingolipid metabolic process
cell cycle
peptide hormone secretion
positive regulation of exosomal secretion
positive regulation of ceramide biosynthetic process
lipid metabolic process
sphingolipid metabolic process
sphingomyelin metabolic process
signal transduction
multicellular organism development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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