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Proteintech
SNAPIN Polyclonal Antibody
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Product Details
10055-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SNAPIN Fusion Protein Ag0101 (1-136 aa encoded by BC000761)
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Amount
52.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody can recognize the 15-18 kDa (Monomer) and 30-36 kDa (Dimer) forms of SNAPIN.
Immunogen sequence: MAGAGSAAV SGAGTPVAGP TGRDLFAEGL LEFLRPAVQQ LDSHVHAVRE SQVELREQID NLATELCRIN EDQKVALDLD PYVKKLLNAR RRVVLVNNIL QNAQERLRRL NHSVAKETAR RRAMLDSGIY PPGSPGK (1-136 aa encoded by BC000761)
Target Information
The protein encoded by this gene is a coiled-coil-forming protein that associates with the SNARE (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor) complex of proteins and the BLOC-1 (biogenesis of lysosome-related organelles) complex. Biochemical studies have identified additional binding partners. As part of the SNARE complex, it is required for vesicle docking and fusion and regulates neurotransmitter release. The BLOC-1 complex is required for the biogenesis of specialized organelles such as melanosomes and platelet dense granules. Mutations in gene products that form the BLOC-1 complex have been identified in mouse strains that are models of Hermansky-Pudlak syndrome. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: biogenesis of lysosomal organelles complex-1, subunit 7; Biogenesis of lysosome-related organelles complex 1 subunit 7; BLOC-1 related complex subunit 3; BLOC-1 subunit 7; SNAP-25-binding protein; SNAP-associated protein; SNARE associated protein snapin; SNARE-associated protein; SNARE-associated protein Snapin; synaptosomal-associated protein 25 binding protein; Synaptosomal-associated protein 25-binding protein; synaptosomal-associated protein, 25 kDa, binding protein; unnamed protein product
Gene Aliases: 25kDa; AA407989; AV026596; BLOC1S7; BLOS7; BORCS3; SNAP25BP; SNAPAP; SNAPIN
UniProt ID: (Human) O95295, (Mouse) Q9Z266, (Rat) P60192
Entrez Gene ID: (Human) 23557, (Mouse) 20615, (Rat) 295217
intracellular protein transport
exocytosis
lysosome organization
lysosomal lumen acidification
chemical synaptic transmission
neurotransmitter secretion
anterograde axonal transport
retrograde axonal transport
endosome to lysosome transport
negative regulation of neuron projection development
synaptic vesicle exocytosis
synaptic vesicle maturation
neuron projection development
protein complex localization
synaptic vesicle fusion to presynaptic active zone membrane
lysosome localization
melanosome organization
synaptic vesicle transport
anterograde synaptic vesicle transport
regulation of endosome size
protein maturation
establishment of vesicle localization
regulation of lysosome size
neuron cellular homeostasis
organelle transport along microtubule
terminal button organization
autophagosome maturation
late endosome to lysosome transport
positive regulation of late endosome to lysosome transport
regulation of synaptic vesicle exocytosis
calcium ion regulated exocytosis
regulation of protein binding
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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