Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
1:200-1:1,000 | View 5 publications 5 publications |
Immunohistochemistry (IHC) |
- | View 1 publication 1 publication |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:50-1:500 | - |
Immunocytochemistry (ICC/IF) |
1:20-1:200 | View 1 publication 1 publication |
Flow Cytometry (Flow) |
0.2 µg/1x10^6 cells | - |
Immunoprecipitation (IP) |
0.5-4.0 µg | - |
Product Specifications | |
---|---|
Species Reactivity |
Human, Mouse, Rat |
Published species |
Human, Mouse |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
SNAPIN Fusion Protein Ag0101 (1-136 aa encoded by BC000761) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.35 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.1% sodium azide |
Storage conditions |
-20°C |
This antibody can recognize the 15-18 kDa (Monomer) and 30-36 kDa (Dimer) forms of SNAPIN.
Immunogen sequence: MAGAGSAAV SGAGTPVAGP TGRDLFAEGL LEFLRPAVQQ LDSHVHAVRE SQVELREQID NLATELCRIN EDQKVALDLD PYVKKLLNAR RRVVLVNNIL QNAQERLRRL NHSVAKETAR RRAMLDSGIY PPGSPGK (1-136 aa encoded by BC000761)
The protein encoded by this gene is a coiled-coil-forming protein that associates with the SNARE (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor) complex of proteins and the BLOC-1 (biogenesis of lysosome-related organelles) complex. Biochemical studies have identified additional binding partners. As part of the SNARE complex, it is required for vesicle docking and fusion and regulates neurotransmitter release. The BLOC-1 complex is required for the biogenesis of specialized organelles such as melanosomes and platelet dense granules. Mutations in gene products that form the BLOC-1 complex have been identified in mouse strains that are models of Hermansky-Pudlak syndrome. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: biogenesis of lysosomal organelles complex-1, subunit 7; Biogenesis of lysosome-related organelles complex 1 subunit 7; BLOC-1 subunit 7; SNAP-25-binding protein; SNAP-associated protein; SNARE associated protein snapin; SNARE-associated protein Snapin; synaptosomal-associated protein 25 binding protein; Synaptosomal-associated protein 25-binding protein; synaptosomal-associated protein, 25 kDa, binding protein
Gene Aliases: 25kDa; AA407989; AV026596; BLOC1S7; BLOS7; BORCS3; SNAP25BP; SNAPAP; SNAPIN
UniProt ID: (Human) O95295, (Mouse) Q9Z266, (Rat) P60192
Entrez Gene ID: (Human) 23557, (Mouse) 20615, (Rat) 295217
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