Recommended positive controls: 293T, A431, Jurkat, mouse heart.
Predicted reactivity: Mouse (100%), Rat (100%), Xenopus laevis (97%), Pig (100%), Chimpanzee (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. The protein plays a role in pre-mRNA processing, possibly tissue-specific alternative splicing events. Although individual snRNPs are believed to recognize specific nucleic acid sequences through RNA-RNA base pairing, the specific role of this family member is unknown. The protein arises from a bicistronic transcript that also encodes a protein identified as the SNRPN upstream reading frame (SNURF). Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5' untranslated region. Additional splice variants have been described but sequences for the complete transcripts have not been determined. The 5' UTR of this gene has been identified as an imprinting center. Alternative splicing or deletion caused by a translocation event in this paternally-expressed region is responsible for Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DKFZp686C0927; DKFZp686M12165; DKFZp761I1912; DKFZp762N022; FE294 gene for snRNP-associated polypeptide N; FE294 psi pseudogene; FLJ33569; FLJ36996; FLJ39265; MGC29886; Sm protein D; SM protein N; Sm-D; Sm-N; small nuclear ribonucleoparticle-associated protein (snRNP) mRNA clone Sm51; small nuclear ribonucleoparticle-associated protein (snRNP) mRNA, clone Sm51; small nuclear ribonucleoprotein N; Small nuclear ribonucleoprotein-associated protein N; smN; snRNP-N; tissue-specific splicing protein; Tissue-specific-splicing protein
Gene Aliases: 2410045I01Rik; FE 294; FE 294 psi; FE294; FE294 psi; HCERN3; Peg4; PWCR; Pwcr1; RT-LI; SM-D; sm-N; SMN; SNRNP-N; SNRPN; SNURF-SNRPN