PA5-30225 targets SNRPN in WB applications and shows reactivity with Human and mouse samples.
The PA5-30225 immunogen is recombinant protein fragment corresponding to a region within amino acids 1 and 137 of Human SNRPN.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. The protein plays a role in pre-mRNA processing, possibly tissue-specific alternative splicing events. Although individual snRNPs are believed to recognize specific nucleic acid sequences through RNA-RNA base pairing, the specific role of this family member is unknown. The protein arises from a bicistronic transcript that also encodes a protein identified as the SNRPN upstream reading frame (SNURF). Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5' untranslated region. Additional splice variants have been described but sequences for the complete transcripts have not been determined. The 5' UTR of this gene has been identified as an imprinting center. Alternative splicing or deletion caused by a translocation event in this paternally-expressed region is responsible for Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure.
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Protein Aliases: HCERN3; PWCR; RT-LI; Sm protein D; SM protein N; SM-D; Sm-N; Small nuclear ribonucleoprotein-associated protein N; SMN; SNRNP-N; SNURF-SNRPN; tissue-specific splicing protein; Tissue-specific-splicing protein
Gene Aliases: 2410045I01Rik; HCERN3; Peg4; PWCR; Pwcr1; RT-LI; SM-D; sm-N; SMN; SNRNP-N; SNRPN; SNURF-SNRPN