Proteintech

SNX17 Polyclonal Antibody

SNX17 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 14

SNX17 Antibody (10275-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using SNX17 antibody 10275-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IGG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).

SNX17 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

SNX17 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

10275-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2400

View 17 publications 17 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 3 publications 3 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SNX17 Fusion Protein Ag0355 (17-226 aa encoded by BC002524)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: GSAYVAYNI HVNGVLHCRV RYSQLLGLHE QLRKEYGANV LPAFPPKKLF SLTPAEVEQR REQLEKYMQA VRQDPLLGSS ETFNSFLRRA QQETQQVPTE EVSLEVLLSN GQKVLVNVLT SDQTEDVLEA VAAKLDLPDD LIGYFSLFLV REKEDGAFSF VRKLQEFELP YVSVTSLRSQ EYKIVLRKSY WDSAYDDDVM ENRVGLNLLY A (17-226 aa encoded by BC002524)

Target Information

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin. Alternative splicing results in multiple transcript variants encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

New insights into the phosphorylation of the threonine motif of the β1 integrin cytoplasmic domain.

Life science alliance

Böttcher RT,Strohmeyer N,Aretz J,Fässler R

Fri Apr 01 00:00:00 UTC 2022

Sorting nexin 17 increases low-density lipoprotein receptor-related protein 4 membrane expression: A novel mechanism of acetylcholine receptor aggregation in myasthenia gravis.

Frontiers in immunology

He X,Zhou S,Ji Y,Zhang Y,Lv J,Quan S,Zhang J,Zhao X,Cui W,Li W,Liu P,Zhang L,Shen T,Fang H,Yang J,Zhang Y,Cui X,Zhang Q,Gao F

Fri Nov 04 00:00:00 UTC 2022

Sorting nexin 17 increases low-density lipoprotein receptor-related protein 4 membrane expression: A novel mechanism of acetylcholine receptor aggregation in myasthenia gravis.

Frontiers in immunology

He X,Zhou S,Ji Y,Zhang Y,Lv J,Quan S,Zhang J,Zhao X,Cui W,Li W,Liu P,Zhang L,Shen T,Fang H,Yang J,Zhang Y,Cui X,Zhang Q,Gao F

Fri Nov 04 00:00:00 UTC 2022

Recycling of autophagosomal components from autolysosomes by the recycler complex.

Nature cell biology

Zhou C,Wu Z,Du W,Que H,Wang Y,Ouyang Q,Jian F,Yuan W,Zhao Y,Tian R,Li Y,Chen Y,Gao S,Wong CCL,Rong Y

Fri Apr 01 00:00:00 UTC 2022

Molecular determinants of αVβ5 localization in flat clathrin lattices - role of αVβ5 in cell adhesion and proliferation.

Journal of cell science

Zuidema A,Wang W,Kreft M,Bleijerveld OB,Hoekman L,Aretz J,Böttcher RT,Fässler R,Sonnenberg A

Wed Jun 01 00:00:00 UTC 2022

The Role of Sorting Nexin 17 in Cardiac Development.

Frontiers in cardiovascular medicine

Wu Y,Zhou Y,Huang J,Ma K,Yuan T,Jiang Y,Ye M,Li J

Fri Jan 07 00:00:00 UTC 2022

A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry.

Nature communications

Zhu Y,Feng F,Hu G,Wang Y,Yu Y,Zhu Y,Xu W,Cai X,Sun Z,Han W,Ye R,Qu D,Ding Q,Huang X,Chen H,Xu W,Xie Y,Cai Q,Yuan Z,Zhang R

Thu Feb 11 00:00:00 UTC 2021

SNX17 protects the heart from doxorubicin-induced cardiotoxicity by modulating LMOD2 degradation.

Pharmacological research

Zhang Y,Ni L,Lin B,Hu L,Lin Z,Yang J,Wang J,Ma H,Liu Y,Yang J,Lin J,Xu L,Wu L,Shi D

Thu Jul 01 00:00:00 UTC 2021

Suppression of Membranous LRP5 Recycling, Wnt/β-Catenin Signaling, and Colon Carcinogenesis by 15-LOX-1 Peroxidation of Linoleic Acid in PI3P.

Cell reports

Liu F,Zuo X,Liu Y,Deguchi Y,Moussalli MJ,Chen W,Yang P,Wei B,Tan L,Lorenzi PL,Gao S,Jaoude JC,Mehdizadeh A,Valentin LA,Wei D,Shureiqi I

Tue Aug 18 00:00:00 UTC 2020

Suppression of Membranous LRP5 Recycling, Wnt/β-Catenin Signaling, and Colon Carcinogenesis by 15-LOX-1 Peroxidation of Linoleic Acid in PI3P.

Cell reports

Liu F,Zuo X,Liu Y,Deguchi Y,Moussalli MJ,Chen W,Yang P,Wei B,Tan L,Lorenzi PL,Gao S,Jaoude JC,Mehdizadeh A,Valentin LA,Wei D,Shureiqi I

Tue Aug 18 00:00:00 UTC 2020

TFEB controls retromer expression in response to nutrient availability.

The Journal of cell biology

Curnock R,Calcagni A,Ballabio A,Cullen PJ

Mon Dec 02 00:00:00 UTC 2019

Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling.

Nature cell biology

McNally KE,Faulkner R,Steinberg F,Gallon M,Ghai R,Pim D,Langton P,Pearson N,Danson CM,Nägele H,Morris LL,Singla A,Overlee BL,Heesom KJ,Sessions R,Banks L,Collins BM,Berger I,Billadeau DD,Burstein E,Cullen PJ

Sun Oct 01 00:00:00 UTC 2017

Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling.

Nature cell biology

Sun Oct 01 00:00:00 UTC 2017

A phosphoinositide conversion mechanism for exit from endosomes.

Nature

Ketel K,Krauss M,Nicot AS,Puchkov D,Wieffer M,Müller R,Subramanian D,Schultz C,Laporte J,Haucke V

Thu Jan 21 00:00:00 UTC 2016

A phosphoinositide conversion mechanism for exit from endosomes.

Nature

Ketel K,Krauss M,Nicot AS,Puchkov D,Wieffer M,Müller R,Subramanian D,Schultz C,Laporte J,Haucke V

Thu Jan 21 00:00:00 UTC 2016

Regulation of Cell Migration and β1 Integrin Trafficking by the Endosomal Adaptor GGA3.

Traffic (Copenhagen, Denmark)

Ratcliffe CD,Sahgal P,Parachoniak CA,Ivaska J,Park M

Wed Jun 01 00:00:00 UTC 2016

Regulation of Cell Migration and β1 Integrin Trafficking by the Endosomal Adaptor GGA3.

Traffic (Copenhagen, Denmark)

Ratcliffe CD,Sahgal P,Parachoniak CA,Ivaska J,Park M

Wed Jun 01 00:00:00 UTC 2016

Regulation of Cell Migration and β1 Integrin Trafficking by the Endosomal Adaptor GGA3.

Traffic (Copenhagen, Denmark)

Ratcliffe CD,Sahgal P,Parachoniak CA,Ivaska J,Park M

Wed Jun 01 00:00:00 UTC 2016

SNX17 affects T cell activation by regulating TCR and integrin recycling.

Journal of immunology (Baltimore, Md. : 1950)

Osborne DG,Piotrowski JT,Dick CJ,Zhang JS,Billadeau DD

Fri May 01 00:00:00 UTC 2015

SNX17 affects T cell activation by regulating TCR and integrin recycling.

Journal of immunology (Baltimore, Md. : 1950)

Osborne DG,Piotrowski JT,Dick CJ,Zhang JS,Billadeau DD

Fri May 01 00:00:00 UTC 2015

SNX17 affects T cell activation by regulating TCR and integrin recycling.

Journal of immunology (Baltimore, Md. : 1950)

Osborne DG,Piotrowski JT,Dick CJ,Zhang JS,Billadeau DD

Fri May 01 00:00:00 UTC 2015

SNX17 affects T cell activation by regulating TCR and integrin recycling.

Journal of immunology (Baltimore, Md. : 1950)

Osborne DG,Piotrowski JT,Dick CJ,Zhang JS,Billadeau DD

Fri May 01 00:00:00 UTC 2015

LRP1 is a receptor for Clostridium perfringens TpeL toxin indicating a two-receptor model of clostridial glycosylating toxins.

Proceedings of the National Academy of Sciences of the United States of America

Schorch B,Song S,van Diemen FR,Bock HH,May P,Herz J,Brummelkamp TR,Papatheodorou P,Aktories K

Tue Apr 29 00:00:00 UTC 2014

LRP1 is a receptor for Clostridium perfringens TpeL toxin indicating a two-receptor model of clostridial glycosylating toxins.

Proceedings of the National Academy of Sciences of the United States of America

Schorch B,Song S,van Diemen FR,Bock HH,May P,Herz J,Brummelkamp TR,Papatheodorou P,Aktories K

Tue Apr 29 00:00:00 UTC 2014

Sorting nexin 31 binds multiple β integrin cytoplasmic domains and regulates β1 integrin surface levels and stability.

Journal of molecular biology

Tseng HY,Thorausch N,Ziegler T,Meves A,Fässler R,Böttcher RT

Tue Sep 09 00:00:00 UTC 2014

Sorting nexin 31 binds multiple β integrin cytoplasmic domains and regulates β1 integrin surface levels and stability.

Journal of molecular biology

Tseng HY,Thorausch N,Ziegler T,Meves A,Fässler R,Böttcher RT

Tue Sep 09 00:00:00 UTC 2014

Sorting nexin 31 binds multiple β integrin cytoplasmic domains and regulates β1 integrin surface levels and stability.

Journal of molecular biology

Tseng HY,Thorausch N,Ziegler T,Meves A,Fässler R,Böttcher RT

Tue Sep 09 00:00:00 UTC 2014

Sorting nexin 17 prevents lysosomal degradation of β1 integrins by binding to the β1-integrin tail.

Nature cell biology

Böttcher RT,Stremmel C,Meves A,Meyer H,Widmaier M,Tseng HY,Fässler R

Sun May 06 00:00:00 UTC 2012

Sorting nexin 17 prevents lysosomal degradation of β1 integrins by binding to the β1-integrin tail.

Nature cell biology

Böttcher RT,Stremmel C,Meves A,Meyer H,Widmaier M,Tseng HY,Fässler R

Sun May 06 00:00:00 UTC 2012

Adaptor protein sorting nexin 17 interacts with the scavenger receptor FEEL-1/stabilin-1 and modulates its expression on the cell surface.

Biochimica et biophysica acta

Adachi H,Tsujimoto M

Sat May 01 00:00:00 UTC 2010

Adaptor protein sorting nexin 17 interacts with the scavenger receptor FEEL-1/stabilin-1 and modulates its expression on the cell surface.

Biochimica et biophysica acta

Adachi H,Tsujimoto M

Sat May 01 00:00:00 UTC 2010

Bioinformatics

Protein Aliases: Sorting nexin-17

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Gene Aliases: 5830447M19Rik; AI790646; b2b1625.1Clo; D5Ertd260e; KIAA0064; mKIAA0064; SNX17

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UniProt ID: (Human) Q15036, (Mouse) Q8BVL3, (Rat) Q6AYS6

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Entrez Gene ID: (Human) 9784, (Mouse) 266781, (Rat) 298836

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Function(s)

receptor binding protein binding protein C-terminus binding phosphatidylinositol binding low-density lipoprotein particle receptor binding lipid binding scaffold/adaptor protein

Process(es)

cardiac septum development cholesterol catabolic process intracellular protein transport receptor-mediated endocytosis signal transduction endosomal transport regulation of endocytosis aorta development coronary vasculature development retrograde transport, endosome to plasma membrane transport protein transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SNX17 Polyclonal Antibody

SNX17 Antibody (10275-1-AP) in ICC/IF

Product Details

10275-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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