Proteintech

SNX17 Polyclonal Antibody

View all (6) SNX17 antibodies

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Questions & Answers

Product Image Gallery

SNX17 Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of HepG2 cells, using SNX17 antibody 10275-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IGG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).

SNX17 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human brain tissue slide using 10275-1-AP ( SNX17 Antibody) at dilution of 1:50 (under 10x lens).

SNX17 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human brain tissue slide using 10275-1-AP ( SNX17 Antibody) at dilution of 1:50 (under 40x lens).

SNX17 Antibody in Western Blot (WB) — Mouse cerebellum tissue were subjected to SDS PAGE followed by western blot with 10275-1-AP (SNX17 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

SNX17 Antibody in Western Blot (WB) — Mouse brain tissue were subjected to SDS PAGE followed by western blot with 10275-1-AP (SNX17 antibody) at dilution of 1:1600 incubated at room temperature for 1.5 hours.

SNX17 Antibody in Western Blot (WB) — Human brain tissue were subjected to SDS PAGE followed by western blot with 10275-1-AP (SNX17 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

SNX17 Antibody in Western Blot (WB) — Mouse skin tissue were subjected to SDS PAGE followed by western blot with 10275-1-AP (SNX17 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

SNX17 Antibody in Western Blot (WB) — Mouse liver tissue were subjected to SDS PAGE followed by western blot with 10275-1-AP (SNX17 antibody) at dilution of 1:0 incubated at room temperature for 1.5 hours.

SNX17 Antibody in Western Blot (WB) — HepG2 cells were subjected to SDS PAGE followed by western blot with 10275-1-AP (SNX17 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

SNX17 Antibody in Western Blot (WB) — HeLa cells were subjected to SDS PAGE followed by western blot with 10275-1-AP (SNX17 antibody) at dilution of 1:1200 incubated at room temperature for 1.5 hours.

SNX17 Antibody in Immunoprecipitation (IP) — IP result of anti-SNX17 (IP:10275-1-AP, 4ug; Detection:10275-1-AP 1:1000) with HeLa cells lysate 1200ug.

Product Details

10275-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2400	View 7 publications 7 publications
Immunohistochemistry (Paraffin) (IHC (P))	1:50-1:200	-
Immunocytochemistry (ICC/IF)	1:20-1:200	View 1 publication 1 publication
Immunoprecipitation (IP)	0.5-4.0 µg	-

Product Specifications
Species Reactivity	Human, Mouse, Rat
Published species	Human, Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	SNX17 Fusion Protein Ag0355 (17-226 aa encoded by BC002524) View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.25 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.1% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: GSAYVAYNI HVNGVLHCRV RYSQLLGLHE QLRKEYGANV LPAFPPKKLF SLTPAEVEQR REQLEKYMQA VRQDPLLGSS ETFNSFLRRA QQETQQVPTE EVSLEVLLSN GQKVLVNVLT SDQTEDVLEA VAAKLDLPDD LIGYFSLFLV REKEDGAFSF VRKLQEFELP YVSVTSLRSQ EYKIVLRKSY WDSAYDDDVM ENRVGLNLLY A (17-226 aa encoded by BC002524)

Target Information

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin. Alternative splicing results in multiple transcript variants encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling.

Nature cell biology

McNally KE,Faulkner R,Steinberg F,Gallon M,Ghai R,Pim D,Langton P,Pearson N,Danson CM,Nägele H,Morris LL,Singla A,Overlee BL,Heesom KJ,Sessions R,Banks L,Collins BM,Berger I,Billadeau DD,Burstein E,Cullen PJ

Sun Oct 01 00:00:00 EDT 2017

A phosphoinositide conversion mechanism for exit from endosomes.

Nature

Ketel K,Krauss M,Nicot AS,Puchkov D,Wieffer M,Müller R,Subramanian D,Schultz C,Laporte J,Haucke V

Thu Jan 21 00:00:00 EST 2016

SNX17 affects T cell activation by regulating TCR and integrin recycling.

Journal of immunology (Baltimore, Md. : 1950)

Osborne DG,Piotrowski JT,Dick CJ,Zhang JS,Billadeau DD

Fri May 01 00:00:00 EDT 2015

SNX17 affects T cell activation by regulating TCR and integrin recycling.

Journal of immunology (Baltimore, Md. : 1950)

Osborne DG,Piotrowski JT,Dick CJ,Zhang JS,Billadeau DD

Fri May 01 00:00:00 EDT 2015

Sorting nexin 31 binds multiple β integrin cytoplasmic domains and regulates β1 integrin surface levels and stability.

Journal of molecular biology

Tseng HY,Thorausch N,Ziegler T,Meves A,Fässler R,Böttcher RT

Tue Sep 09 00:00:00 EDT 2014

Sorting nexin 31 binds multiple β integrin cytoplasmic domains and regulates β1 integrin surface levels and stability.

Journal of molecular biology

Tseng HY,Thorausch N,Ziegler T,Meves A,Fässler R,Böttcher RT

Tue Sep 09 00:00:00 EDT 2014

LRP1 is a receptor for Clostridium perfringens TpeL toxin indicating a two-receptor model of clostridial glycosylating toxins.

Proceedings of the National Academy of Sciences of the United States of America

Schorch B,Song S,van Diemen FR,Bock HH,May P,Herz J,Brummelkamp TR,Papatheodorou P,Aktories K

Tue Apr 29 00:00:00 EDT 2014

Sorting nexin 17 prevents lysosomal degradation of β1 integrins by binding to the β1-integrin tail.

Nature cell biology

Böttcher RT,Stremmel C,Meves A,Meyer H,Widmaier M,Tseng HY,Fässler R

Sun May 06 00:00:00 EDT 2012

Adaptor protein sorting nexin 17 interacts with the scavenger receptor FEEL-1/stabilin-1 and modulates its expression on the cell surface.

Biochimica et biophysica acta

Adachi H,Tsujimoto M

Sat May 01 00:00:00 EDT 2010

Bioinformatics

Protein Aliases: Sorting nexin-17

Gene Aliases: 5830447M19Rik; AI790646; b2b1625.1Clo; D5Ertd260e; KIAA0064; mKIAA0064; SNX17

UniProt ID: (Human) Q15036, (Mouse) Q8BVL3, (Rat) Q6AYS6

Entrez Gene ID: (Human) 9784, (Mouse) 266781, (Rat) 298836

Molecular Function: scaffold/adaptor protein

cardiac septum development cholesterol catabolic process intracellular protein transport receptor-mediated endocytosis signal transduction endosomal transport regulation of endocytosis aorta development coronary vasculature development retrograde transport, endosome to plasma membrane transport protein transport

Process(es)

receptor binding protein binding protein C-terminus binding phosphatidylinositol binding low-density lipoprotein particle receptor binding lipid binding