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Fabgennix
SOCS1 Polyclonal Antibody
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Product Details
SOCS1-101AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 170-212 on human Suppressor of Cytokine signaling 1 protein.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The Suppressor of cytokine signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular proteins which regulate the immune cell responses to cytokines. SOCS1 acts to suppress dendritic cell (DC) as well as T cell hyperactivation following cytokine signaling by inhibiting JAK tyrosine kinase, a kinase necessary for type I and II cytokine receptors to initiate signaling, by directly binding to the catalytic domain of the kinase. SOCS1 also possesses E3 ubiquitin protein ligase activity that results in the polyubiquitination of its target proteins and subsequent degradation by the proteosome. It is through this method that SOCS1 negatively regulates signaling by Toll-like receptors TLR2 and TLR4 by mediating the degradation of the TLR signaling adaptor protein TIRAP.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cytokine inducible SH2-containing protein 1; cytokine inducible SH2-containing protein 7; cytokine-inducible SH2 protein 1; JAB; JAK binding protein; JAK-binding protein; JAK2-binding protein; SOCS-1; SSI-1; STAT induced SH3 protein 1; STAT-induced STAT inhibitor 1; Suppressor of cytokine signaling 1; Tec-interacting protein 3; TIP-3; unnamed protein product
Gene Aliases: AISIMD; CIS1; CISH1; Cish7; JAB; SOCS-1; SOCS1; SSI-1; SSI1; TIP-3; TIP3
UniProt ID: (Human) O15524, (Mouse) O35716
Entrez Gene ID: (Human) 8651, (Mouse) 12703, (Rat) 252971
regulation of cytokine production
JAK-STAT cascade
negative regulation of signal transduction
protein ubiquitination
cytokine-mediated signaling pathway
macrophage differentiation
developmental process
intracellular signal transduction
positive regulation of CD4-positive, alpha-beta T cell differentiation
negative regulation of CD8-positive, alpha-beta T cell differentiation
fat cell differentiation
positive regulation of regulatory T cell differentiation
regulation of JAK-STAT cascade
negative regulation of JAK-STAT cascade
negative regulation of insulin receptor signaling pathway
cellular response to amino acid stimulus
regulation of protein phosphorylation
negative regulation of protein kinase activity
regulation of activation of JAK2 kinase activity
regulation of growth
regulation of tyrosine phosphorylation of Stat1 protein
negative regulation of tyrosine phosphorylation of Stat3 protein
negative regulation of catalytic activity
regulation of cytokine secretion
regulation of interferon-gamma-mediated signaling pathway
organ regeneration
response to estradiol
response to lipopolysaccharide
response to progesterone
response to cytokine
response to drug
response to peptide hormone
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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