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Fabgennix
SOCS3 Polyclonal Antibody, FITC
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Product Details
SOCS3-FITC
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 175-225 on human SOCS3 protein.
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Accumulating evidence demonstrates that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules Termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family have been recognized, they are SOCS-1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CIS-3; cytokine inducible SH2-containing protein 3; Cytokine-inducible SH2 protein 3; E2a-Pbx1 target gene in fibroblasts 10; MGC71791; Protein EF-10; SOCS-3; SOCS3; SSI-3; STAT-induced STAT inhibitor 3; Suppressor of cytokine signaling 3; unnamed protein product
Gene Aliases: ATOD4; CIS3; Cish3; EF-10; Ef10; SOCS-3; SOCS3; SSI-3; SSI3
UniProt ID: (Human) O14543, (Mouse) O35718, (Rat) O88583
Entrez Gene ID: (Human) 9021, (Mouse) 12702, (Rat) 89829
signal transduction
JAK-STAT cascade
negative regulation of signal transduction
protein ubiquitination
cytokine-mediated signaling pathway
cell differentiation
intracellular signal transduction
negative regulation of apoptotic process
positive regulation of cell differentiation
negative regulation of JAK-STAT cascade
negative regulation of insulin receptor signaling pathway
negative regulation of inflammatory response
branching involved in labyrinthine layer morphogenesis
placenta blood vessel development
interleukin-6-mediated signaling pathway
T-helper 17 cell lineage commitment
cellular response to interleukin-17
cellular response to leukemia inhibitory factor
regulation of protein phosphorylation
negative regulation of protein kinase activity
regulation of growth
regulation of cell differentiation
trophoblast giant cell differentiation
spongiotrophoblast differentiation
regulation of cell growth
response to hypoxia
aging
response to heat
response to bacterium
response to hormone
response to gamma radiation
response to organic cyclic compound
organ regeneration
response to food
response to estradiol
response to lipopolysaccharide
response to progesterone
response to insulin
response to cytokine
response to drug
response to peptide hormone
response to glucocorticoid
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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