|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide region of human SOX18.|
|Storage buffer||PBS with 2% sucrose|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||2 µg/ml|
PA1-24474 detects SOX18 in Human samples.
PA1-24474 has been successfully used in Western Blot procedures.
PA1-24474 immunogen corresponds to Polyclonal antibody from rabbits immunized with a synthetic peptide region of human SOX18.
SOX18 a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. This protein plays a role in hair, blood vessel, and lymphatic vessel development. Mutations in this gene have been associated with recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia.
TNF¿-induced down-regulation of Sox18 in endothelial cells is dependent on NF-¿B.
PA1-24474 was used in western blot to study the role of NFkB in the mechanism by which TNF-alpha downregulates endothelial Sox18 expression
|Basílio J,Hoeth M,Holper-Schichl YM,Resch U,Mayer H,Hofer-Warbinek R,de Martin R||Biochemical and biophysical research communications (442:221)||2013|
The transcription factor SOX18 regulates the expression of matrix metalloproteinase 7 and guidance molecules in human endothelial cells.
PA1-24474 was used in ChIP assay to study the target genes of transcription factor SOX18 in human endothelial cells
|Hoeth M,Niederleithner H,Hofer-Warbinek R,Bilban M,Mayer H,Resch U,Lemberger C,Wagner O,Hofer E,Petzelbauer P,de Martin R||PloS one (7:null)||2012|