Display Info:
cookie.CK_ISO_CODE.value:us
cookie.CK_LANG_CODE.value:en
cookie.CK_DISPLAY_TYPE.value:
pageContext.request:org.apache.struts2.dispatcher.StrutsRequestWrapper@31a7aa2e
Request attributes: pageContext.request.scheme:http(not used)
syndicationProtocol:https
syndicationExtensionPrefix:.secure
syndicationDisplayType:
      LOADING ...

      System Message

      OKCancel

      SOX18 Polyclonal Antibody

      See 2 other SOX18 antibodies ›
      SOX18 Polyclonal Antibody for Western Blot

      Catalog#: PA1-24474 Invitrogen

      Catalog # Size Price (USD) Qty Datasheet
      PA1-24474 100 µg
      399.00
      Please enter a quantity in the range of 1 to 199.
      Suggested Secondary Antibodies

      Anti-Rabbit Secondary Antibodies (264)
      Alexa Fluor® Anti-Rabbit Secondary Antibodies (69)
      HRP Anti-Rabbit Secondary Antibodies (30)

      Product Details

      References

      Bioinformatics

      Documents
      Details
      Tested species reactivity Human
      Published species reactivity Human
      Host / Isotype Rabbit / IgG
      Class Polyclonal
      Type Antibody
      Immunogen Synthetic peptide region of human SOX18.
      Conjugate Unconjugated
      Form Liquid
      Concentration 1 mg/ml
      Purification IgG fraction
      Storage buffer PBS with 2% sucrose
      Contains no preservative
      Storage Conditions -20° C, Avoid Freeze/Thaw Cycles
      Tested Applications Dilution *
      Western Blot (WB) 2 µg/ml

      * Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.

      Published Applications
      Western Blot (WB) See 1 publications below
      ChIP assay (ChIP) See 1 publications below

      Product Specific Information

      PA1-24474 detects SOX18 in Human samples.

      PA1-24474 has been successfully used in Western Blot procedures.

      PA1-24474 immunogen corresponds to Polyclonal antibody from rabbits immunized with a synthetic peptide region of human SOX18.

      Background/Target Information

      SOX18 a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. This protein plays a role in hair, blood vessel, and lymphatic vessel development. Mutations in this gene have been associated with recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia.

      For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

      References

      Western Blot

      Species Dilution Title Authors Journal (Vol:Pg) Year
      Human 2 ug/ml TNF¿-induced down-regulation of Sox18 in endothelial cells is dependent on NF-¿B.
      PA1-24474 was used in western blot to study the role of NFkB in the mechanism by which TNF-alpha downregulates endothelial Sox18 expression       		Basílio J,Hoeth M,Holper-Schichl YM,Resch U,Mayer H,Hofer-Warbinek R,de Martin R Biochemical and biophysical research communications (442:221) 2013

      ChIP assay

      Species Dilution Title Authors Journal (Vol:Pg) Year
      Human Not Cited The transcription factor SOX18 regulates the expression of matrix metalloproteinase 7 and guidance molecules in human endothelial cells.
      PA1-24474 was used in ChIP assay to study the target genes of transcription factor SOX18 in human endothelial cells       		Hoeth M,Niederleithner H,Hofer-Warbinek R,Bilban M,Mayer H,Resch U,Lemberger C,Wagner O,Hofer E,Petzelbauer P,de Martin R PloS one (7:null) 2012

      Documents

      Material safety data sheets (MSDS)

      Display Info:
      cookie.CK_ISO_CODE.value:us
      cookie.CK_LANG_CODE.value:en
      cookie.CK_DISPLAY_TYPE.value:
      pageContext.request.scheme:http(not used)
      syndicationProtocol:https
      syndicationExtensionPrefix:.secure
      syndicationDisplayType: