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Invitrogen
SP100 Polyclonal Antibody
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FIGURE: 1 / 2
SP100 Antibody (PA5-85701) in ICC/IF
SP100 Polyclonal Antibody detects SP100 protein at P-body and nucleus by immunofluorescent analysis. Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: SP100 protein stained by SP100 Polyclonal Antibody (Product # PA5-85701) diluted at 1:500. Blue: Hoechst 33342 staining. Scale bar = 10 µm.
Product Details
PA5-85701
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the N-terminus region of human SP100. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
2.6 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Keep as concentrated solution.
Positive Control: A431, HeLa, HepG2.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp686E07254; FLJ00340; FLJ34579; Nuclear autoantigen Sp-100; Nuclear dot-associated Sp100 protein; SP 100; SP100-HMG nuclear autoantigen; Speckled 100 kDa
Gene Aliases: lysp100b; SP100
UniProt ID: (Human) P23497
Entrez Gene ID: (Human) 6672
negative regulation of transcription from RNA polymerase II promoter
telomere maintenance
transcription, DNA-templated
inflammatory response
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
negative regulation of endothelial cell migration
viral process
protein sumoylation
response to type I interferon
response to interferon-gamma
negative regulation of DNA binding
negative regulation of sequence-specific DNA binding transcription factor activity
regulation of angiogenesis
positive regulation of transcription, DNA-templated
negative regulation of protein export from nucleus
negative regulation of cellular component movement
interferon-gamma-mediated signaling pathway
type I interferon signaling pathway
regulation of extrinsic apoptotic signaling pathway via death domain receptors
regulation of Fas signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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