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Proteintech
SPAST Polyclonal Antibody
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Product Details
22792-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SPAST Fusion Protein Ag18797 (79-278 aa encoded by BC150260)
Conjugate
Form
Liquid
Concentration
0.44 mg/mL
Amount
66 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: CQRFSRALM AAKRSSGAAP APASASAPAP VPGGEAERVR VFHKQAFEYI SIALRIDEDE KAGQKEQAVE WYKKGIEELE KGIAVIVTGQ GEQCERARRL QAKMMTNLVM AKDRLQLLES GAVPKRKDPL THTSNSLPRS KTVMKTGSAG LSGHHRAPSY SGLSMVSGVK QGSGPAPTTH KGTPKTNRTN KPSTPTTATR K (79-278 aa encoded by BC150260)
Target Information
This gene encodes a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. The encoded ATPase may be involved in the assembly or function of nuclear protein complexes. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequences have not been determined. Mutations associated with this gene cause the most frequent form of autosomal dominant spastic paraplegia 4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: fidgetin-like 1; KIAA183; spastic paraplegia 4 (autosomal dominant; spastic paraplegia 4 (autosomal dominant; spastin); spastic paraplegia 4 homolog; Spastic paraplegia 4 protein; Spastin; spastin {ECO:0000255|HAMAP-Rule:MF_03021}; unnamed protein product
Gene Aliases: ADPSP; FSP2; KIAA1083; mKIAA1083; SPAST; SPG4
UniProt ID: (Human) Q9UBP0, (Mouse) Q9QYY8, (Rat) B2RYN7
Entrez Gene ID: (Human) 6683, (Mouse) 50850, (Rat) 362700
mitotic cytokinesis
microtubule bundle formation
ER to Golgi vesicle-mediated transport
mitotic nuclear envelope reassembly
nervous system development
axonogenesis
anterograde axonal transport
exit from mitosis
axonal transport of mitochondrion
central nervous system neuron axonogenesis
cell differentiation
positive regulation of microtubule depolymerization
nuclear envelope reassembly
positive regulation of cytokinesis
cytokinetic process
protein hexamerization
microtubule severing
mitotic spindle disassembly
protein homooligomerization
cell division
cytoskeleton-dependent cytokinesis
membrane fission
cell cycle
multicellular organism development
metabolic process
cytoplasmic microtubule organization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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