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Proteintech
SPDYA Polyclonal Antibody
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Product Details
17836-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SPDYA Fusion Protein Ag12041 (1-313 aa encoded by BC093005)
Conjugate
Form
Liquid
Concentration
0.29 mg/mL
Amount
43.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MRHNQMCCE TPPTVTVYVK SGSNRSHQPK KPITLKRPIC KDNWQAFEKN THNNNKSKRP KGPCLVIQRQ DMTAFFKLFD DDLIQDFLWM DCCCKIADKY LLAMTFVYFK RAKFTISEHT RINFFIALYL ANTVEEDEEE TKYEIFPWAL GKNWRKLFPN FLKLRDQLWD RIDYRAIVSR RCCEEVMAIA PTHYIWQRER SVHHSGAVRN YNRDEVQLPR GPSATPVDCS LCGKKRRYVR LGLSSSSSLS SHTAGVTEKH SQDSYNSLSM DIIGDPSQAY TGSEVVNDHQ SNKGKKTNFL KKDKSMEWFT GSEE (1-313 aa encoded by BC093005)
Target Information
Speedy A, also known as SPDYA, SPDY1, Ringo3 or SPY1, is a 313 amino acid protein that localizes to the nucleus and belongs to the speedy/ringo family. Expressed at high levels in testis and at lower levels in brain, kidney, heart, bone marrow, colon, lung, liver spleen and placenta, Speedy A functions to regulate the G1/S phase transition of the cell cycle, specifically by binding to and activating Cdc2 p34, Cdk2 and p27. Additionally, Speedy A mediates cell survival during DNA damage, suggesting that Speedy A plays a role in proper cell cycle progression throughout the life of the cell. Multiple isoforms of Speedy A exist due to alternative splicing events. The gene encoding Speedy A maps to human chromosome 2, which encodes over 1,400 genes and comprises nearly 8% of the human genome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epididymis secretory sperm binding protein; GS4; hSpy/Ringo A; MLZ-465; mSpy/Ringo A; Protein expressed in male leptotene and zygotene spermatocytes 465; Rapid inducer of G2/M progression in oocytes A; RINGO A; spdya; spdya {ECO:0000250|UniProtKB:Q5MJ70}; speedy A; speedy A1; speedy A2; speedy homolog 1; speedy homolog A; Speedy protein A; Speedy-1; speedy/ringo; speedy/ringo A2; spermatogenesis related protein Gs4; Spy1; Spy1; speedy/ringo A1
Gene Aliases: 4921517J08Rik; 4930548B21Rik; GS4; Lm23; MLZ-465; RINGO3; RINGOA; SPDY1; SPDYA; SPY1
UniProt ID: (Human) Q5MJ70, (Mouse) Q5IBH7, (Rat) Q8R496
Entrez Gene ID: (Human) 245711, (Mouse) 70891, (Rat) 192209
G1/S transition of mitotic cell cycle
cellular response to DNA damage stimulus
cell cycle
multicellular organism development
positive regulation of cell proliferation
positive regulation of cyclin-dependent protein serine/threonine kinase activity
male meiosis
spermatogenesis
telomere capping
positive regulation of protein kinase activity
oogenesis
meiotic attachment of telomere to nuclear envelope
establishment of protein localization to telomere
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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