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Immunogen sequence: AEYTHKSPRV HSLILCNSFS DTSIFNQTWT ANSFWLMPAF MLKKIVLGNF SSGPVDPMMA DAIDFMVDRL ESLGQSELAS RLT
Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 99%.
The protein encoded by this gene was identified by a two-hybrid screen using CD4 as the bait. It binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4. At least three different transcript variants encoding two different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Acid cluster protein 33; Maspardin; Spastic paraplegia 21 autosomal recessive Mast syndrome protein; Spastic paraplegia 21 protein
Gene Aliases: ACP33; BM-019; GL010; MAST; SPG21
UniProt ID: (Human) Q9NZD8
Entrez Gene ID: (Human) 51324
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