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Abnova
SPHK1 Polyclonal Antibody, MaxPab™
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FIGURE: 1 / 1
SPHK1 Antibody (H00008877-D01P) in WB
Western Blot analysis of SPHK1 expression in transfected 293T cell line (H00008877-T02) by SPHK1 MaxPab polyclonal antibody.
Lane 1: SPHK1 transfected lysate(43.90 KDa).
Lane 2: Non-transfected lysate.
Lane 1: SPHK1 transfected lysate(43.90 KDa).
Lane 2: Non-transfected lysate.
Product Details
H00008877-D01P
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SPHK1 (NP_068807.2, 1 a.a. approximately 398 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
See Label
Amount
100 µg
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MDPVVGCGRG LFGFVFSAGG PRGVLPRPCR VLVLLNPRGG KGKALQLFRS HVQPLLAEAE ISFTLMLTER RNHARELVRS EELGRWDALV VMSGDGLMHE VVNGLMERPD WETAIQKPLC SLPAGSGNAL AASLNHYAGY EQVTNEDLLT NCTLLLCRRL LSPMNLLSLH TASGLRLFSV LSLAWGFIAD VDLESEKYRR LGEMRFTLGT FLRLAALRTY RGRLAYLPVG RVGSKTPASP VVVQQGPVDA HLVPLEEPVP SHWTVVPDED FVLVLALLHS HLGSEMFAAP MGRCAAGVMH LFYVRAGVSR AMLLRLFLAM EKGRHMEYEC PYLVYVPVVA FRLEPKDGKG VFAVDGELMV SEAVQGQVHP NYFWMVSGCV EPPPSWKPQQ MPPPEEPL
Target Information
SPHK1, along with SPHK2, catalyzes the phosphorylation of sphingosine producing the signaling molecule sphingosine-1-phosphate (S1P). S1P signals through G-protein coupled receptors and controls diverse cellular processes. Inhibitors of SPHKs are viewed as potential therapeutics for the treatment of cancer. SPHK1 catalyzes the phosphorylation of sphingosine to sphingosine 1 phosphate (S1P), an important signaling molecule with intra- and extracellular functions. Inside the cell S1P acts as a signaling molecule like other sphingolipid metabolites like ceramide and sphingosine. S1P has been implicated in regulating cell differentiation, calcium mobilization from intracellular stores, and apoptosis. The cell surface receptors for S1P are the EDG family of G protein-coupled receptors (S1P Receptors).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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