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Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Prf; Pu.1-related factor; Spi-C transcription factor (Spi-1/PU.1 related); Transcription factor Spi-C
Gene Aliases: AU019198; C76795; Prf; SPI-C; SPIC
UniProt ID: (Human) Q8N5J4, (Mouse) Q6P3D7
Entrez Gene ID: (Human) 121599, (Mouse) 20728
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